N-Desethyl amodiaquine-d5
Based on 1 Customer Validation
N-Desethyl amodiaquine-d5 is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 1173023-19-2
- Formula: C18H13D5ClN3O
- Molecular Weight:332.84
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1173023-19-2
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Unlabeled CAS 79352-78-6
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Appearance Solid
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Molecular Weight 332.84
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Formula C18H13D5ClN3O
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Color Light yellow to yellow
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SMILES
ClC(C=C1)=CC2=C1C(NC3=CC(CNC([2H])([2H])C([2H])([2H])[2H])=C(C=C3)O)=CC=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (300.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0044 mL | 15.0222 mL | 30.0445 mL | 75.1112 mL |
| 5 mM | 0.6009 mL | 3.0044 mL | 6.0089 mL | 15.0222 mL | |
| 10 mM | 0.3004 mL | 1.5022 mL | 3.0044 mL | 7.5111 mL | |
| 15 mM | 0.2003 mL | 1.0015 mL | 2.0030 mL | 5.0074 mL | |
| 20 mM | 0.1502 mL | 0.7511 mL | 1.5022 mL | 3.7556 mL | |
| 25 mM | 0.1202 mL | 0.6009 mL | 1.2018 mL | 3.0044 mL | |
| 30 mM | 0.1001 mL | 0.5007 mL | 1.0015 mL | 2.5037 mL | |
| 40 mM | 0.0751 mL | 0.3756 mL | 0.7511 mL | 1.8778 mL | |
| 50 mM | 0.0601 mL | 0.3004 mL | 0.6009 mL | 1.5022 mL | |
| 60 mM | 0.0501 mL | 0.2504 mL | 0.5007 mL | 1.2519 mL | |
| 80 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9389 mL | |
| 100 mM | 0.0300 mL | 0.1502 mL | 0.3004 mL | 0.7511 mL |
N-Desethyl amodiaquine-d5 Related Classifications
HY-128554S Related Classifications
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