79352-78-6
79352-78-6
Chemical Structure
N-Desethyl amodiaquine
- CAS No.: 79352-78-6
- Formula:C18H18ClN3O
- Molecular Weight:327.81
IUPAC Name: 4-((7-chloroquinolin-4-yl)amino)-2-((ethylamino)methyl)phenol
InChIKey: VRXFDHAGFYWGHT-UHFFFAOYSA-N
SMILES: OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CNCC
Biological Activity: N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria[1][2].
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N-Desethyl amodiaquine | 99.98% | N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria. | ||||||||||||||||||||
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N-Desethyl amodiaquine-d5 | 99.9% | N-Desethyl amodiaquine-d5 is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively. | ||||||||||||||||||||
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N-Desethyl amodiaquine-d5 dihydrochloride | 98.76% | N-Desethyl amodiaquine-d5 dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively. | ||||||||||||||||||||
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References
- [1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]
- [2]. Xue-Qing Li, et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. [Content Brief]
