Cat. No.: HY-B1322A

Amodiaquine

Name: Amodiaquine
Brand: MedChemExpress
SKU: HY-B1322A
Price: 130.00 USD
Availability: InStock
Rating: 5 (12 reviews)

(Synonyms: Amodiaquin)

12 Cited Publications

고객리뷰

Based on 12 publication(s) in Google Scholar

Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.62%
CAS No.: 86-42-0
화학식: C₂₀H₂₂ClN₃O
분자량:355.86

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Amodiaquine Chemical Structure

CAS No.: 86-42-0

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (12)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Plasmodium

Nurr1/NR4A2

All Nuclear Hormone Receptor 4A/NR4A Isoforms :

All Parasite Isoforms :

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	CC₅₀	52.09 μM Compound: Amodiaquine	Cytotoxicity against BHK21 cells after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against BHK21 cells after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 26771861]
CHO	IC₅₀	147.157 μM Compound: Amodiaquine	Cytotoxicity against CHO cells by MTT assay Cytotoxicity against CHO cells by MTT assay	[PMID: 26264839]
SH-SY5Y	CC₅₀	10 μM Compound: AQ	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 29559198]
Vero	CC₅₀	>50 μM Compound: Amodiaquine	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	EC₅₀	2.8 μM Compound: Amodiaquine	Antiviral activity against Zika virus PLCal_ZV infected in African green monkey Vero cells assessed as reduction in viral titer after 1 hr by plaque assay Antiviral activity against Zika virus PLCal_ZV infected in African green monkey Vero cells assessed as reduction in viral titer after 1 hr by plaque assay	[PMID: 31549836]
Vero	IC₅₀	5.15 μM Compound: Amodiaquine	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730

In Vitro

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner^[1].
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH⁺ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

Primary microglia
Concentration:

10 µM, 15 µM, 20 µM
Incubation Time:

4 hours
Result:

Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.

In Vivo

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ICR mice (8-10 weeks of age) induced ntracerebral hemorrhage (ICH)^[2]
Dosage:

40 mg/kg
Administration:

Intraperitoneal injection; daily; for 3 days
Result:

Diminished perihematomal activation of microglia/macrophages and astrocytes.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 86-42-0
Appearance Solid
분자량 355.86
화학식 C₂₀H₂₂ClN₃O
Color White to light yellow
SMILES

OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CN(CC)CC
Synonyms

Amodiaquin
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (12)

All Bio/Physico-chemical AssayFlow CytometryIn Vivo Efficacy StudyWB

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Journal Impact Factor

Adv Sci (Weinh)

Amodiaquine Enhances Anti-Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils. [Abstract]

2026 Jan 26:e15009. PMID: 41588921

Amodiaquine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 26:e15009. [Abstract]

IC₅₀ values of AQ (Amodiaquine) for neutrophils.

Amodiaquine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 26:e15009. [Abstract]

Effects of AQ (Amodiaquine, 100 mg/kg per mouse, 100 µL per mouse, daily, ip) on neutrophil phagocytosis of VNP-RFP in vitro and in vivo.

Amodiaquine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 26:e15009. [Abstract]

Tumor growth curve after VNP combined with AQ (Amodiaquine) treatment.

Amodiaquine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 26:e15009. [Abstract]

Distribution of VNP in the mouse heart, liver, spleen, lung, kidney, and tumor after combined treatment with VNP and AQ (Amodiaquine). The dilution ratio of the tissue homogenate is indicated in the corresponding panel.

Amodiaquine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 26:e15009. [Abstract]

Changes in the proportion of neutrophils among immune cells in the blood of mice following treatment with VNP combined with AQ (Amodiaquine).

Amodiaquine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 26:e15009. [Abstract]

The effect of high concentrations of AQ (Amodiaquine, 800 μM) on the interaction between target proteins and AQ (Amodiaquine)-P (20 μM).
Pharmacol Res

Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex. [Abstract]

2023 May:191:106717. PMID: 36948326
BMC Chem

Development and experimental validation of a machine learning model for the prediction of new antimalarials. [Abstract]

2025 Jan 30;19(1):28. PMID: 39885590
Bioorg Chem

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]

2024 Jun:147:107412. PMID: 38696845
Cell Signal

Paeoniflorin-6'-O-benzene sulfonate inhibits keratinocyte proliferation by restoring GRK2-JAK1 colocalization in mouse model of psoriasis. [Abstract]

2025 Jul:131:111706. PMID: 40037425
J Virol

An RNA replicon system to investigate promising inhibitors of feline coronavirus. [Abstract]

2024 Feb 20;98(2):e0121623. PMID: 38236006
Metab Brain Dis

The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway. [Abstract]

2021 Apr;36(4):609-625. PMID: 33507465
Biochem Biophys Res Commun

Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]

2020 Feb 19;522(4):862-868. PMID: 31806372
Biol Pharm Bull

Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer. [Abstract]

2022 Apr 1;45(4):438-445. PMID: 35110426
Cell Press Blue

2026 Apr 22.
Research Square Print

September 20th, 2022.
Oxid Med Cell Longev

2021 Feb 10.

용액&용해도

In Vitro:

DMSO : 66.67 mg/mL (187.35 mM; ultrasonic and adjust pH to 3 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8101 mL

14.0505 mL

28.1009 mL

5 mM

0.5620 mL

2.8101 mL

5.6202 mL

10 mM

0.2810 mL

1.4050 mL

2.8101 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. [Content Brief]

[2]. Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. [Content Brief]

[3]. Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. [Content Brief]

[4]. M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8101 mL	14.0505 mL	28.1009 mL	70.2523 mL
	5 mM	0.5620 mL	2.8101 mL	5.6202 mL	14.0505 mL
	10 mM	0.2810 mL	1.4050 mL	2.8101 mL	7.0252 mL
	15 mM	0.1873 mL	0.9367 mL	1.8734 mL	4.6835 mL
	20 mM	0.1405 mL	0.7025 mL	1.4050 mL	3.5126 mL
	25 mM	0.1124 mL	0.5620 mL	1.1240 mL	2.8101 mL
	30 mM	0.0937 mL	0.4683 mL	0.9367 mL	2.3417 mL
	40 mM	0.0703 mL	0.3513 mL	0.7025 mL	1.7563 mL
	50 mM	0.0562 mL	0.2810 mL	0.5620 mL	1.4050 mL
	60 mM	0.0468 mL	0.2342 mL	0.4683 mL	1.1709 mL
	80 mM	0.0351 mL	0.1756 mL	0.3513 mL	0.8782 mL
	100 mM	0.0281 mL	0.1405 mL	0.2810 mL	0.7025 mL

Bioz

Keywords

Amodiaquine

12 Cited Publications

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Amodiaquine

Publications Citing Use of MedChemExpress (MCE) Amodiaquine

All Nuclear Hormone Receptor 4A/NR4A Isoforms

All Parasite Isoforms

All Histone Methyltransferase Isoforms