1. Immunology/Inflammation
  2. COX
  3. Phenacetin

Phenacetin (Synonyms: Acetophenetidin)

Cat. No.: HY-B0476 Purity: 99.09%
Handling Instructions

Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.

For research use only. We do not sell to patients.

Phenacetin Chemical Structure

Phenacetin Chemical Structure

CAS No. : 62-44-2

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10 mM * 1 mL in DMSO USD 55 In-stock
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5 g USD 96 In-stock
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Description

Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity. Target: COX Phenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].

IC50 & Target[1]

COX-3

102 μM (IC50)

Molecular Weight

179.22

Formula

C₁₀H₁₃NO₂

CAS No.

62-44-2

SMILES

CC(NC1=CC=C(OCC)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (557.97 mM)

H2O : 0.67 mg/mL (3.74 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5797 mL 27.8987 mL 55.7973 mL
5 mM 1.1159 mL 5.5797 mL 11.1595 mL
10 mM 0.5580 mL 2.7899 mL 5.5797 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PhenacetinAcetophenetidinCOXCyclooxygenaseInhibitorinhibitorinhibit

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Phenacetin
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