62-44-2
62-44-2
Chemical Structure
Phenacetin
Synonym(s): Acetophenetidin
- CAS. Nr.: 62-44-2
- Formula:C10H13NO2
- Molecular Weight:179.22
IUPAC Name: N-(4-ethoxyphenyl)acetamide
InChIKey: CPJSUEIXXCENMM-UHFFFAOYSA-N
SMILES: CC(NC1=CC=C(OCC)C=C1)=O
Biological Activity: Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Phenacetin | 99.95% | Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. | ||||||||||||||||||||
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Phenacetin (Standard) | 99.86% | Phenacetin (Standard) is the analytical standard of Phenacetin. This product is intended for research and analytical applications. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. | ||||||||||||||||||||
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Phenacetin-13C | 99.9% | Phenacetin-13C is the 13C labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. | ||||||||||||||||||||
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Phenacetin-13C-1 | Phenacetin-13C-1 (Acetophenetidin-13C-1) is the 13C-labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. | |||||||||||||||||||||
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Phenacetin-d5 | 99.51% | Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. | ||||||||||||||||||||
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N-(4-Ethoxyphenyl)acetamide-2,2,2-d3 | N-(4-Ethoxyphenyl)acetamide-2,2,2-d3 is the deuterium labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. | |||||||||||||||||||||
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4-Acetamidophenyl acetate (Standard) | ≥98% | 4-Acetamidophenyl acetate (Standard) is the analytical standard of 4-Acetamidophenyl acetate (HY-66004). This product is intended for research and analytical applications. 4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||||||||||||||||||||
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Acetaminophen | 99.97% | Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model. | ||||||||||||||||||||
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Acetaminophen-d3 | 98.63% | Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||||||||||||||||||||
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Acetaminophen-13C6 | Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | |||||||||||||||||||||
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Acetaminophen-13C2,15N | 98.30% | Acetaminophen-13C2,15N is the 13C and 15N labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||||||||||||||||||||
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N-(4-Chlorophenyl)acetamide (Standard) | ≥98% | N-(4-Chlorophenyl)acetamide (Standard) is the analytical standard of N-(4-Chlorophenyl)acetamide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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4-Methoxybenzyl acetate-d3 | 4-Methoxybenzyl acetate-d3 is deuterated labeled 4-Methoxybenzyl acetate. | |||||||||||||||||||||
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2-Ethoxyphenol-d5 | 2-Ethoxyphenol-d5 is the deuterium labeled 2-Ethoxyphenol. | |||||||||||||||||||||
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Methacetin-methoxy-13C | 98.85% | Methacetin-methoxy-13C is the 13C labeled Methacetin-methoxy. | ||||||||||||||||||||
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2-(2-Ethoxyphenoxy)acetic acid-d5 | 2-(2-Ethoxyphenoxy)acetic acid-d5 is the deuterium labeled 2-(2-Ethoxyphenoxy)acetic acid. | |||||||||||||||||||||
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Dulcin | 98.58% | Dulcin is an artificial sweetener. | ||||||||||||||||||||
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3-Ethoxyphenol-d5 | 3-Ethoxyphenol-d5 (Resorcinol monoethyl ether-d5) is the deuterium labeled 3-Ethoxyphenol. 3-Ethoxyphenol (Resorcinol monoethyl ether) is a phosphine ligand that can be used to evaluate the hydrogen bond acceptor ability of solutes. | |||||||||||||||||||||
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4-Ethoxyaniline-d5 hydrochloride | 4-Ethoxyaniline-d5 hydrochloride (p-Phenetidinium chloride-d5) is the deuterium labeled 4-Ethoxyaniline hydrochloride (HY-W128859). | |||||||||||||||||||||
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References
- [1]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. [Content Brief]
- [2]. Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7(10): 1725–1731. [Content Brief]
- [3]. Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9(2): e89752. [Content Brief]
