2. Immunology/Inflammation
  3. COX
  4. Phenacetin-d5

Phenacetin-d5  (Synonyms: Acetophenetidin-d5)

製品番号: HY-B0476S 純度: 99.51%
COA 取扱説明書 Technical Support

Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats.

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Phenacetin-d<sub>5</sub>

Phenacetin-d5 構造式

CAS 番号 : 69323-74-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 在庫あり
Solution
10 mM * 1 mL in DMSO USD 165 在庫あり
Solid
1 mg $60 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg $150 在庫あり
10 mg $250 在庫あり
25 mg $500 在庫あり
50 mg $800 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Other Forms of Phenacetin-d5:

Phenacetin-d5 関連抗体

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COX アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
COX COX-1 COX-2 COX-3

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製品説明

Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenacetin-d5 関連抗体
分子量

184.25

分子式

C10H8D5NO2
CAS 番号
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

CC(NC1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])[2H])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (542.74 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.67 mg/mL (3.64 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4274 mL 27.1370 mL 54.2741 mL
5 mM 1.0855 mL 5.4274 mL 10.8548 mL
10 mM 0.5427 mL 2.7137 mL 5.4274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.4274 mL 27.1370 mL 54.2741 mL 135.6852 mL
DMSO 5 mM 1.0855 mL 5.4274 mL 10.8548 mL 27.1370 mL
10 mM 0.5427 mL 2.7137 mL 5.4274 mL 13.5685 mL
15 mM 0.3618 mL 1.8091 mL 3.6183 mL 9.0457 mL
20 mM 0.2714 mL 1.3569 mL 2.7137 mL 6.7843 mL
25 mM 0.2171 mL 1.0855 mL 2.1710 mL 5.4274 mL
30 mM 0.1809 mL 0.9046 mL 1.8091 mL 4.5228 mL
40 mM 0.1357 mL 0.6784 mL 1.3569 mL 3.3921 mL
50 mM 0.1085 mL 0.5427 mL 1.0855 mL 2.7137 mL
60 mM 0.0905 mL 0.4523 mL 0.9046 mL 2.2614 mL
80 mM 0.0678 mL 0.3392 mL 0.6784 mL 1.6961 mL
100 mM 0.0543 mL 0.2714 mL 0.5427 mL 1.3569 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Phenacetin-d5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenacetin-d569323-74-6Acetophenetidin-d5COXCyclooxygenaseInhibitorinhibitorinhibit

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製品番号:
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