2. Immunology/Inflammation
  3. COX
  4. Phenacetin-d5

Phenacetin-d5  (Synonyms: Acetophenetidin-d5)

Cat. No.: HY-B0476S Purity: 98.51%
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Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

For research use only. We do not sell to patients.

Phenacetin-d<sub>5</sub> Chemical Structure

Phenacetin-d5 Chemical Structure

CAS No. : 69323-74-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 347 In-stock
Solution
10 mM * 1 mL in DMSO USD 347 In-stock
Solid
1 mg USD 108 In-stock
5 mg USD 315 In-stock
10 mg USD 500 In-stock
25 mg USD 1000 In-stock
50 mg USD 1600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Phenacetin-d5:

Phenacetin-d5 Related Antibodies

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Description

Phenacetin-d5 is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenacetin-d5 Related Antibodies
Molecular Weight

184.25

Formula

C10H8D5NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(NC1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (542.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4274 mL 27.1370 mL 54.2741 mL
5 mM 1.0855 mL 5.4274 mL 10.8548 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4274 mL 27.1370 mL 54.2741 mL 135.6852 mL
5 mM 1.0855 mL 5.4274 mL 10.8548 mL 27.1370 mL
10 mM 0.5427 mL 2.7137 mL 5.4274 mL 13.5685 mL
15 mM 0.3618 mL 1.8091 mL 3.6183 mL 9.0457 mL
20 mM 0.2714 mL 1.3569 mL 2.7137 mL 6.7843 mL
25 mM 0.2171 mL 1.0855 mL 2.1710 mL 5.4274 mL
30 mM 0.1809 mL 0.9046 mL 1.8091 mL 4.5228 mL
40 mM 0.1357 mL 0.6784 mL 1.3569 mL 3.3921 mL
50 mM 0.1085 mL 0.5427 mL 1.0855 mL 2.7137 mL
60 mM 0.0905 mL 0.4523 mL 0.9046 mL 2.2614 mL
80 mM 0.0678 mL 0.3392 mL 0.6784 mL 1.6961 mL
100 mM 0.0543 mL 0.2714 mL 0.5427 mL 1.3569 mL
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Phenacetin-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenacetin-d569323-74-6Acetophenetidin-d5COXCyclooxygenaseInhibitorinhibitorinhibit

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