N-Desethyl amodiaquine-d₅ dihydrochloride

Cat. No.: HY-128554S1 Purity: 98.76%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

N-Desethyl amodiaquine-d₅ dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC₅₀ values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively.

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N-Desethyl amodiaquine-d<sub>5</sub> dihydrochloride

N-Desethyl amodiaquine-d₅ dihydrochloride 화학구조

CAS No. : 1216894-33-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	견적 받기
50 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of N-Desethyl amodiaquine-d₅ dihydrochloride:

N-Desethyl amodiaquine In-stock
N-Desethyl amodiaquine-d₅ In-stock

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•Related Proteins:

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

405.76

화학식

C₁₈H₁₅D₅Cl₃N₃O

CAS No.

1216894-33-5

Unlabeled CAS

79352-78-6

Appearance

Solid

Color

White to yellow

SMILES

ClC1=CC2=C(C(NC3=CC(CNC([2H])(C([2H])([2H])[2H])[2H])=C(O)C=C3)=CC=N2)C=C1.Cl.Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H2O : 100 mg/mL (246.45 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4645 mL	12.3226 mL	24.6451 mL
5 mM	0.4929 mL	2.4645 mL	4.9290 mL
10 mM	0.2465 mL	1.2323 mL	2.4645 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.53%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (257 KB) HNMR (147 KB) RP-HPLC (122 KB) MS (168 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	2.4645 mL	12.3226 mL	24.6451 mL	61.6128 mL
	5 mM	0.4929 mL	2.4645 mL	4.9290 mL	12.3226 mL
	10 mM	0.2465 mL	1.2323 mL	2.4645 mL	6.1613 mL
	15 mM	0.1643 mL	0.8215 mL	1.6430 mL	4.1075 mL
	20 mM	0.1232 mL	0.6161 mL	1.2323 mL	3.0806 mL
	25 mM	0.0986 mL	0.4929 mL	0.9858 mL	2.4645 mL
	30 mM	0.0822 mL	0.4108 mL	0.8215 mL	2.0538 mL
	40 mM	0.0616 mL	0.3081 mL	0.6161 mL	1.5403 mL
	50 mM	0.0493 mL	0.2465 mL	0.4929 mL	1.2323 mL
	60 mM	0.0411 mL	0.2054 mL	0.4108 mL	1.0269 mL
	80 mM	0.0308 mL	0.1540 mL	0.3081 mL	0.7702 mL
	100 mM	0.0246 mL	0.1232 mL	0.2465 mL	0.6161 mL