N-Desethyl amodiaquine-d5 dihydrochloride
Based on 1 Customer Validation
N-Desethyl amodiaquine-d5 dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively.
For research use only. We do not sell to patients.
- Purity : 98.76%
- CAS No.: 1216894-33-5
- Formula: C18H15D5Cl3N3O
- Molecular Weight:405.76
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1216894-33-5
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Unlabeled CAS 79352-78-6
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Appearance Solid
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Molecular Weight 405.76
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Formula C18H15D5Cl3N3O
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Color White to yellow
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SMILES
ClC1=CC2=C(C(NC3=CC(CNC([2H])(C([2H])([2H])[2H])[2H])=C(O)C=C3)=CC=N2)C=C1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (246.45 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4645 mL | 12.3226 mL | 24.6451 mL | 61.6128 mL |
| 5 mM | 0.4929 mL | 2.4645 mL | 4.9290 mL | 12.3226 mL | |
| 10 mM | 0.2465 mL | 1.2323 mL | 2.4645 mL | 6.1613 mL | |
| 15 mM | 0.1643 mL | 0.8215 mL | 1.6430 mL | 4.1075 mL | |
| 20 mM | 0.1232 mL | 0.6161 mL | 1.2323 mL | 3.0806 mL | |
| 25 mM | 0.0986 mL | 0.4929 mL | 0.9858 mL | 2.4645 mL | |
| 30 mM | 0.0822 mL | 0.4108 mL | 0.8215 mL | 2.0538 mL | |
| 40 mM | 0.0616 mL | 0.3081 mL | 0.6161 mL | 1.5403 mL | |
| 50 mM | 0.0493 mL | 0.2465 mL | 0.4929 mL | 1.2323 mL | |
| 60 mM | 0.0411 mL | 0.2054 mL | 0.4108 mL | 1.0269 mL | |
| 80 mM | 0.0308 mL | 0.1540 mL | 0.3081 mL | 0.7702 mL | |
| 100 mM | 0.0246 mL | 0.1232 mL | 0.2465 mL | 0.6161 mL |
N-Desethyl amodiaquine-d5 dihydrochloride Related Classifications
HY-128554S1 Related Classifications
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