N-Desethyl amodiaquine dihydrochloride
Based on 1 publication(s) in Google Scholar
N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria.
For research use only. We do not sell to patients.
- Purity : 99.88%
- CAS No.: 79049-30-2
- Formula: C18H20Cl3N3O
- Molecular Weight:400.73
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-128554AR
N-Desethyl amodiaquine dihydrochloride (Standard) -
HY-128554
N-Desethyl amodiaquine -
HY-B0770
Artemotil -
HY-10852
Arterolane -
HY-13801
Fexinidazole -
HY-B2138
Ethopabate -
HY-103033
T.cruzi-IN-1 -
HY-12642
Diethylcarbamazine citrate -
HY-10852R
Arterolane (Standard) -
HY-B2138R
Ethopabate (Standard) -
HY-13801R
Fexinidazole (Standard) -
HY-12642R
Diethylcarbamazine citrate (Standard)
Publications Citing Use of MedChemExpress (MCE) N-Desethyl amodiaquine dihydrochloride
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Biological Activity
Description
In Vitro
N-Desethyl amodiaquine dihydrochloride has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 79049-30-2
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Appearance Solid
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Molecular Weight 400.73
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Formula C18H20Cl3N3O
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Color Light yellow to yellow
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SMILES
OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CNCC.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (249.54 mM; Need ultrasonic)
DMSO : 62.5 mg/mL (155.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.19 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.19 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (249.54 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Korean - KR (796 KB)
- Portuguese - PT (796 KB)
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Handling Instructions (2659 KB)
References
[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [Content Brief]
[2]. Xue-Qing Li, et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.4954 mL | 12.4772 mL | 24.9545 mL | 62.3861 mL |
| 5 mM | 0.4991 mL | 2.4954 mL | 4.9909 mL | 12.4772 mL | |
| 10 mM | 0.2495 mL | 1.2477 mL | 2.4954 mL | 6.2386 mL | |
| 15 mM | 0.1664 mL | 0.8318 mL | 1.6636 mL | 4.1591 mL | |
| 20 mM | 0.1248 mL | 0.6239 mL | 1.2477 mL | 3.1193 mL | |
| 25 mM | 0.0998 mL | 0.4991 mL | 0.9982 mL | 2.4954 mL | |
| 30 mM | 0.0832 mL | 0.4159 mL | 0.8318 mL | 2.0795 mL | |
| 40 mM | 0.0624 mL | 0.3119 mL | 0.6239 mL | 1.5597 mL | |
| 50 mM | 0.0499 mL | 0.2495 mL | 0.4991 mL | 1.2477 mL | |
| 60 mM | 0.0416 mL | 0.2080 mL | 0.4159 mL | 1.0398 mL | |
| 80 mM | 0.0312 mL | 0.1560 mL | 0.3119 mL | 0.7798 mL | |
| 100 mM | 0.0250 mL | 0.1248 mL | 0.2495 mL | 0.6239 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Desethyl amodiaquine dihydrochloride Related Classifications
HY-128554A Related Classifications
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