1. GPCR/G Protein
  2. Bradykinin Receptor

Bradykinin 1-5 

Cat. No.: HY-P1488
Handling Instructions

Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). Sequence: Arg-Pro-Pro-Gly-Phe;RPPGF.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bradykinin 1-5 Chemical Structure

Bradykinin 1-5 Chemical Structure

CAS No. : 23815-89-6

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). Sequence: Arg-Pro-Pro-Gly-Phe;RPPGF.

In Vivo

Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min[1].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7462 mL 8.7312 mL 17.4624 mL
5 mM 0.3492 mL 1.7462 mL 3.4925 mL
10 mM 0.1746 mL 0.8731 mL 1.7462 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

572.66

Formula

C₂₇H₄₀N₈O₆

CAS No.

23815-89-6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Bradykinin 1-5
Cat. No.:
HY-P1488
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Bradykinin 1-5

Cat. No.: HY-P1488