1. Cell Cycle/DNA Damage
    Anti-infection
    Metabolic Enzyme/Protease
  2. DNA/RNA Synthesis
    SARS-CoV
    RSV
    HCV
    Drug Metabolite
  3. GS-443902 trisodium

GS-443902 trisodium (Synonyms: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium)

Cat. No.: HY-126303C Purity: 99.15%
Handling Instructions

GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).

For research use only. We do not sell to patients.

GS-443902 trisodium Chemical Structure

GS-443902 trisodium Chemical Structure

CAS No. : 1355050-21-3

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1 mg USD 980 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2].

IC50 & Target

IC50: 1.1 µM (RSV RdRp) and 5 µM (HCV RdRp)[1][2]

In Vitro

In a continuous 72 h incubation of 1 µM Remdesivir (GS-5734), the GS-443902 trisodium (GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium) level is measured at 2, 24, 48 and 72 h, and reaches a Cmax of 300, 110, and 90 pmol/million cells in macrophages, HMVEC, and HeLa cells lines respectively[1].
GS-443902 trisodium (compound 8a) is a triphosphates (TP) derivative[2].
GS-443902 trisodium (NTP; 0.01, 0.1, 1, 10, 100 μM) inhibits RSV RdRp-catalysed RNA synthesis by incorporating into the nascent viral RNA transcript and causing its premature termination. GS-5734 selectively inhibits EBOV replication by targeting its RdRp and inhibiting viral RNA synthesis following efficient intracellular conversion to GS-443902 sodium[3].

In Vivo

Remdesivir (GS-5734; 10 mg kg; i.v.) rapidly distributes into peripheral blood mononuclear cells (PBMCs), and efficient conversion to GS-443902 trisodium (Remdesivir metabolite trisodium; NTP) is apparent within 2 h of dose administration in rhesus monkeys. In PBMCs, GS-443902 trisodium represents the predominant metabolite and is persistent with a t1/2 of 14 h and levels required for >50% virus inhibition for 24 hours[3].

Molecular Weight

597.15

Formula

C₁₂H₁₃N₅Na₃O₁₃P₃

CAS No.

1355050-21-3

SMILES

O=P(OP(O)(O[Na])=O)(O[Na])OP(OC[[email protected]@H](O1)[[email protected]@H](O)[[email protected]@H](O)[[email protected]]1(C#N)C2=CC=C3N2N=CN=C3N)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

Solvent & Solubility
In Vitro: 

H2O : 300 mg/mL (502.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6746 mL 8.3731 mL 16.7462 mL
5 mM 0.3349 mL 1.6746 mL 3.3492 mL
10 mM 0.1675 mL 0.8373 mL 1.6746 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

GS-443902 trisodiumGS-441524 triphosphate trisodiumRemdesivir metabolite trisodiumDNA/RNA SynthesisSARS-CoVRSVHCVDrug MetaboliteSARS coronavirusRespiratory syncytial virusHepatitis C virustriphosphatemetaboliteRemdesivirGS-5734RNA-dependentRNA-polymerasesRdRpTPGS-441524Inhibitorinhibitorinhibit

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GS-443902 trisodium
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HY-126303C
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