1355050-21-3
Chemical Structure
GS-443902 trisodium
Synonym(s): GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium
- CAS No.: 1355050-21-3
- Formula:C12H13N5Na3O13P3
- Molecular Weight:597.15
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChIKey: SLVVSIUNIVFLJS-AZIZZYAFSA-K
SMILES: O=P(OP(O)(O[Na])=O)(O[Na])OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O[Na])=O
Biological Activity: GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GS-443902 trisodium | 99.94% | GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734). | ||||||||||||||||||||
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- [1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. [Content Brief]
- [2]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. [Content Brief]
Keywords
