Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

  • Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. doi: 10.1016/j.bmcl.2012.02.105.
Aesop Cho  1 ,  Oliver L Saunders ,  Thomas Butler ,  Lijun Zhang ,  Jie Xu ,  Jennifer E Vela ,  Joy Y Feng ,  Adrian S Ray ,  Choung U Kim
Affiliations
PMID: 22446091 DOI: 10.1016/j.bmcl.2012.02.105
Abstract

A series of 1'-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as Antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R=CN was attributed to inhibition of HCV NS5B Polymerase and intracellular concentration of the corresponding nucleoside triphosphate.

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