HCV NS5B Polymerase
Hepatitis C virus (HCV) NS5B polymerase is a crucial RNA-dependent RNA polymerase (RdRp) responsible for replicating the viral RNA genome, making it a key target for antiviral drug development.
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HCV NS5B Polymerase (1)
Roseoside
Cat. No.: HY-N1341
CAS No.: 54835-70-0
- Formula: C19H30O8
- Molecular Weight: 386.44
Roseoside is an inhibitor of DNA gyrase and HAV 3C protease, and also inhibits HCV NS5A/B replicase in human systems with an IC50 of 20 μM. Roseoside binds to the active site of enzymes and stabilizes the interaction by forming hydrogen bonds with key amino acid residues. Roseoside inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, and Candida albicans, and interferes with HCV RNA replication in vitro by inhibiting HCV NS5A/B replicase (IC50=20 μM). Roseoside shows no cytotoxicity and serves as a research tool for studies related to bacterial infections, candidiasis, HAV and HCV.
