N-Acetylputrescine
Based on 1 publication(s) in Google Scholar
N-Acetylputrescine is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD).
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 5699-41-2
- Formula: C6H14N2O
- Molecular Weight:130.19
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) N-Acetylputrescine
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
N-Acetylputrescine is identified as a characteristic component in the peptidoglycan of the cyanobacteria Glaucocystis nostochinearum and Cyanoptyche gloeocystis, and participates in the composition of the cell wall structure by modifying D-glutamic acid residues[1].
N-Acetylputrescine (radiolabeled; 72 h) is synthesized from putrescine in human lymphocyte culture and can be released into the culture medium. Its production is related to the cell proliferation state and may be involved in the regulation of polyamine metabolism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5699-41-2
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Appearance Liquid (Density: 0.948±0.06 g/cm3)
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Molecular Weight 130.19
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Formula C6H14N2O
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Color Colorless to light yellow
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SMILES
CC(NCCCCN)=O
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Synonyms
NAP
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Dec 8. PMID: 41361241
Solvent & Solubility
DMSO : 100 mg/mL (768.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (768.11 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
[1]. Pfanzagl B, et al. N-acetylputrescine as a characteristic constituent of cyanelle peptidoglycan in glaucocystophyte algae. J Bacteriol. 1996 Dec;178(23):6994-7. [Content Brief]
[2]. Menashe M, et al. Formulation of N-acetylputrescine and N1-acetylspermidine in cultured human lymphocytes. Biochem J. 1980 Apr 15;188(1):263-7. [Content Brief]
[3]. Liu R, et al. Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs. Oncotarget. 2017 Jul 17;8(51):88575-88585. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 7.6811 mL | 38.4054 mL | 76.8108 mL | 192.0270 mL |
| 5 mM | 1.5362 mL | 7.6811 mL | 15.3622 mL | 38.4054 mL | |
| 10 mM | 0.7681 mL | 3.8405 mL | 7.6811 mL | 19.2027 mL | |
| 15 mM | 0.5121 mL | 2.5604 mL | 5.1207 mL | 12.8018 mL | |
| 20 mM | 0.3841 mL | 1.9203 mL | 3.8405 mL | 9.6014 mL | |
| 25 mM | 0.3072 mL | 1.5362 mL | 3.0724 mL | 7.6811 mL | |
| 30 mM | 0.2560 mL | 1.2802 mL | 2.5604 mL | 6.4009 mL | |
| 40 mM | 0.1920 mL | 0.9601 mL | 1.9203 mL | 4.8007 mL | |
| 50 mM | 0.1536 mL | 0.7681 mL | 1.5362 mL | 3.8405 mL | |
| 60 mM | 0.1280 mL | 0.6401 mL | 1.2802 mL | 3.2005 mL | |
| 80 mM | 0.0960 mL | 0.4801 mL | 0.9601 mL | 2.4003 mL | |
| 100 mM | 0.0768 mL | 0.3841 mL | 0.7681 mL | 1.9203 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Acetylputrescine Related Classifications
HY-W342604 Related Classifications
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