Cat. No.: HY-113100

N-Acetylputrescine hydrochloride

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

N-Acetylputrescine hydrochloride is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine hydrochloride may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine hydrochloride can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine hydrochloride can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD).

For research use only. We do not sell to patients.

Purity: 99.0%
CAS No.: 18233-70-0
Formula: C₆H₁₅ClN₂O
Molecular Weight:166.65

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

N-Acetylputrescine hydrochloride Chemical Structure

CAS No.: 18233-70-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

N-Acetylputrescine hydrochloride is identified as a characteristic component in the peptidoglycan of the cyanobacteria Glaucocystis nostochinearum and Cyanoptyche gloeocystis, and participates in the composition of the cell wall structure by modifying D-glutamic acid residues^[1].
N-Acetylputrescine hydrochloride (radiolabeled; 72 h) is synthesized from putrescine in human lymphocyte culture and can be released into the culture medium. Its production is related to the cell proliferation state and may be involved in the regulation of polyamine metabolism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The concentration of N-Acetylputrescine hydrochloride in the 3-methylcholanthrene-induced rat lung squamous cell carcinoma (SCCL) model increases significantly with cancer progression. After treatment with anticancer agents, the concentration of N-Acetylputrescine hydrochloride decreases, suggesting that it could serve as a potential biomarker for the early diagnosis and evaluation of SCC^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 18233-70-0
Appearance Solid
Molecular Weight 166.65
Formula C₆H₁₅ClN₂O
Color White to off-white
SMILES

CC(NCCCCN)=O.Cl
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Nat Commun

Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis. [Abstract]

2025 Dec 8. PMID: 41361241

Solvent & Solubility

In Vitro:

H₂O : 200 mg/mL (1200.12 mM; Need ultrasonic)

DMSO : ≥ 125 mg/mL (750.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.0006 mL

30.0030 mL

60.0060 mL

5 mM

1.2001 mL

6.0006 mL

12.0012 mL

10 mM

0.6001 mL

3.0003 mL

6.0006 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (12.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (12.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (12.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (600.06 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pfanzagl B, et al. N-acetylputrescine as a characteristic constituent of cyanelle peptidoglycan in glaucocystophyte algae. J Bacteriol. 1996 Dec;178(23):6994-7. [Content Brief]

[2]. Menashe M, et al. Formulation of N-acetylputrescine and N1-acetylspermidine in cultured human lymphocytes. Biochem J. 1980 Apr 15;188(1):263-7. [Content Brief]

[3]. Liu R, et al. Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs. Oncotarget. 2017 Jul 17;8(51):88575-88585. [Content Brief]

[4]. Peng K W, et al. Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinson's Disease Biomarker Panel[J]. bioRxiv, 2021: 2021.07. 23.453542.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	6.0006 mL	30.0030 mL	60.0060 mL	150.0150 mL
	5 mM	1.2001 mL	6.0006 mL	12.0012 mL	30.0030 mL
	10 mM	0.6001 mL	3.0003 mL	6.0006 mL	15.0015 mL
	15 mM	0.4000 mL	2.0002 mL	4.0004 mL	10.0010 mL
	20 mM	0.3000 mL	1.5002 mL	3.0003 mL	7.5008 mL
	25 mM	0.2400 mL	1.2001 mL	2.4002 mL	6.0006 mL
	30 mM	0.2000 mL	1.0001 mL	2.0002 mL	5.0005 mL
	40 mM	0.1500 mL	0.7501 mL	1.5002 mL	3.7504 mL
	50 mM	0.1200 mL	0.6001 mL	1.2001 mL	3.0003 mL
	60 mM	0.1000 mL	0.5001 mL	1.0001 mL	2.5003 mL
	80 mM	0.0750 mL	0.3750 mL	0.7501 mL	1.8752 mL
	100 mM	0.0600 mL	0.3000 mL	0.6001 mL	1.5002 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

N-Acetylputrescine hydrochloride

1 Cited Publications

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N-Acetylputrescine hydrochloride

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Publications Citing Use of MedChemExpress (MCE) N-Acetylputrescine hydrochloride

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

N-Acetylputrescine hydrochloride Related Classifications

HY-113100 Related Classifications