N1-Acetylspermidine hydrochloride
Based on 1 Customer Validation
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 34450-16-3
- Formula: C9H23Cl2N3O
- Molecular Weight:260.20
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Metabolism/Protease Compound Library
HY-L012
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Natural Product Library
HY-L021
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Anti-Cancer Compound Library
HY-L025
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Anti-Colorectal Cancer Compound Library
HY-L103
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Anti-Cancer Natural Product Library
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All Endogenous Metabolite Isoforms
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Biological Activity
N1-Acetylspermidine (1 mM) hydrochloride is less efficient than Spermidine (HY-B1776) and N8-acetylspermidine (HY-113253A) in inducing DNA cleavage at apurinic sites[3].
N1-Acetylspermidine (500 μM) hydrochloride combined with Procyanidins can increase the proportion of apoptotic SW620 cells (colon cancer cell line)[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 34450-16-3
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Appearance Solid
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Molecular Weight 260.20
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Formula C9H23Cl2N3O
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Color White to light yellow
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SMILES
CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 25 mg/mL (96.08 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. [Content Brief]
[2]. Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7. [Content Brief]
[3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. [Content Brief]
[4]. Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2(10):pgad306. [Content Brief]
[5]. Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29(2):423-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8432 mL | 19.2160 mL | 38.4320 mL | 96.0799 mL |
| 5 mM | 0.7686 mL | 3.8432 mL | 7.6864 mL | 19.2160 mL | |
| 10 mM | 0.3843 mL | 1.9216 mL | 3.8432 mL | 9.6080 mL | |
| 15 mM | 0.2562 mL | 1.2811 mL | 2.5621 mL | 6.4053 mL | |
| 20 mM | 0.1922 mL | 0.9608 mL | 1.9216 mL | 4.8040 mL | |
| 25 mM | 0.1537 mL | 0.7686 mL | 1.5373 mL | 3.8432 mL | |
| 30 mM | 0.1281 mL | 0.6405 mL | 1.2811 mL | 3.2027 mL | |
| 40 mM | 0.0961 mL | 0.4804 mL | 0.9608 mL | 2.4020 mL | |
| 50 mM | 0.0769 mL | 0.3843 mL | 0.7686 mL | 1.9216 mL | |
| 60 mM | 0.0641 mL | 0.3203 mL | 0.6405 mL | 1.6013 mL | |
| 80 mM | 0.0480 mL | 0.2402 mL | 0.4804 mL | 1.2010 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N1-Acetylspermidine hydrochloride Related Classifications
HY-113056A Related Classifications
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