34450-16-3
34450-16-3
Chemical Structure
N1-Acetylspermidine hydrochloride
- CAS No.: 34450-16-3
- Formula:C9H23Cl2N3O
- Molecular Weight:260.20
IUPAC Name: N-(3-((4-aminobutyl)amino)propyl)acetamide dihydrochloride
InChIKey: IVLOLMVLUOGVCZ-UHFFFAOYSA-N
SMILES: CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl
Biological Activity: N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research[1][2][3][4][5].
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N1-Acetylspermidine hydrochloride | 99.88% | N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research. | ||||||||||||||||||||
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N1-Acetylspermidine hydrochloride (Standard) | ≥98% | N1-Acetylspermidine (hydrochloride) (Standard) is the analytical standard of N1-Acetylspermidine (hydrochloride). This product is intended for research and analytical applications. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research. | ||||||||||||||||||||
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N1-Acetylspermidine-d6 hydrochloride | N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA. | |||||||||||||||||||||
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N1-Acetylspermidine-d3 hydrochloride | N1-Acetylspermidine-d3 hydrochloride is the deuterium labeled N1-Acetylspermidine hydrochloride (HY-113056A). N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research. | |||||||||||||||||||||
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References
- [1]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. [Content Brief]
- [2]. Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7. [Content Brief]
- [3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. [Content Brief]
- [4]. Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2(10):pgad306. [Content Brief]
- [5]. Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29(2):423-8. [Content Brief]
