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Cat. No.: HY-W700539

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N1-Acetyl triethylenetetramine

N1-Acetyl triethylenetetramine is a polyamine derivative with a free amino terminus. N1-Acetyl triethylenetetramine serves as a substrate for spermidine/spermine N1-acetyltransferase (SSAT) and exerts competitive inhibitory effects on APAO and SMO. N1-Acetyl triethylenetetramine can be catalyzed to undergo acetylation by recombinant mouse SSAT. It is applicable in metabolism-related research.

For research use only. We do not sell to patients.

CAS No.: 141998-21-2
Formula: C₈H₂₀N₄O
Molecular Weight:188.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

N1-Acetyl triethylenetetramine Chemical Structure

CAS No.: 141998-21-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

N1-Acetyl triethylenetetramine (compound 3b) serves as a substrate for recombinant mouse SSAT, with a K_m value of 79 μM and a V_max value of 0.57 (μmol/min)/mg SSAT, and exhibits substrate inhibition at concentrations exceeding 250 μM^[1].
N1-Acetyl triethylenetetramine (100-2000 μM) dose-dependently inhibits the activity of recombinant mouse SSAT^[1].
N1-Acetyl triethylenetetramine (100-1000 μM) inhibits the activity of recombinant human APAO in a dose-dependent manner; when competing with N1-acetylspermine, it reduces APAO activity to 75% of that in the control group at a concentration of 1000 μM. It also inhibits the activity of recombinant human SMO in a dose-dependent manner; when competing with spermine, it reduces SMO activity to 30% of that in the control group at a concentration of 1000 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 141998-21-2
Molecular Weight 188.27
Formula C₈H₂₀N₄O
SMILES

O=C(C)NCCNCCNCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Weisell J, et al. Synthesis and biological characterization of novel charge-deficient spermine analogues. Journal of medicinal chemistry. 2010 Aug 12;53(15):5738-48. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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