Spermidine-d6
Based on 1 publication(s) in Google Scholar
Spermidine-d6 is the deuterium labeled Spermidine. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents.
For research use only. We do not sell to patients.
- Purity: 96.07%
- CAS No.: 2514812-10-1
- Formula: C7H13D6N3
- Molecular Weight:151.28
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Spermidine-d6
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2514812-10-1
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Unlabeled Cas 124-20-9
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Appearance Solid-Liquid Mixture
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Molecular Weight 151.28
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Formula C7H13D6N3
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Color Colorless to light yellow
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SMILES
NC([2H])([2H])C([2H])([2H])C([2H])([2H])NCCCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Metab
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis. [Abstract]2025 Oct 10:S1550-4131(25)00434-6. PMID: 41075780
Solvent & Solubility
H2O : ≥ 50 mg/mL (330.51 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Zhang L, et al. The Alleviation of Heat Damage to Photosystem II and Enzymatic Antioxidants by Exogenous Spermidine in Tall Fescue. Front Plant Sci. 2017 Oct 12;8:1747. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.6103 mL | 33.0513 mL | 66.1026 mL | 165.2565 mL |
| 5 mM | 1.3221 mL | 6.6103 mL | 13.2205 mL | 33.0513 mL | |
| 10 mM | 0.6610 mL | 3.3051 mL | 6.6103 mL | 16.5256 mL | |
| 15 mM | 0.4407 mL | 2.2034 mL | 4.4068 mL | 11.0171 mL | |
| 20 mM | 0.3305 mL | 1.6526 mL | 3.3051 mL | 8.2628 mL | |
| 25 mM | 0.2644 mL | 1.3221 mL | 2.6441 mL | 6.6103 mL | |
| 30 mM | 0.2203 mL | 1.1017 mL | 2.2034 mL | 5.5085 mL | |
| 40 mM | 0.1653 mL | 0.8263 mL | 1.6526 mL | 4.1314 mL | |
| 50 mM | 0.1322 mL | 0.6610 mL | 1.3221 mL | 3.3051 mL | |
| 60 mM | 0.1102 mL | 0.5509 mL | 1.1017 mL | 2.7543 mL | |
| 80 mM | 0.0826 mL | 0.4131 mL | 0.8263 mL | 2.0657 mL | |
| 100 mM | 0.0661 mL | 0.3305 mL | 0.6610 mL | 1.6526 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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