1. Metabolic Enzyme/Protease
    Apoptosis
  2. Endogenous Metabolite
    Apoptosis
  3. 3-Hydroxykynurenine

3-Hydroxykynurenine (Synonyms: 3-Hydroxy-DL-kynurenine)

Cat. No.: HY-113294
Handling Instructions

3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.

For research use only. We do not sell to patients.

3-Hydroxykynurenine Chemical Structure

3-Hydroxykynurenine Chemical Structure

CAS No. : 484-78-6

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Description

3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1]
3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1].
3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1].
3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2].
3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: CD3/CD28 bead-stimulated CD4+ T cells
Concentration: 0, 20, 40, 60, 80, and 100 μM
Incubation Time: 72 hours
Result: Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM.
In Vivo

3-Hydroxykynurenine administration (560 mg/kg IP on a daily basis on days 1 to 7, days 7 to 14, or days 1 to 14) results in significant prolongation of graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (H2d) mice[2]
Dosage: 560 mg/kg
Administration: IP injection
Result: There was significant prolongation of graft survival in all treatment groups in comparison to the controls.
Molecular Weight

224.21

Formula

C₁₀H₁₂N₂O₄

CAS No.
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Storage

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3-Hydroxykynurenine
Cat. No.:
HY-113294
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