1. Metabolic Enzyme/Protease Apoptosis
  2. Endogenous Metabolite Apoptosis
  3. 3-Hydroxykynurenine

3-Hydroxykynurenine  (Synonyms: 3-Hydroxy-DL-kynurenine)

Cat. No.: HY-113294 Purity: 99.33%
COA Handling Instructions

3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.

For research use only. We do not sell to patients.

3-Hydroxykynurenine Chemical Structure

3-Hydroxykynurenine Chemical Structure

CAS No. : 484-78-6

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 3-Hydroxykynurenine:

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  • Biological Activity

  • Purity & Documentation

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Description

3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1].?
3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1].
3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1].
3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+?T-cell proliferation in a dose-dependent manner with IC50?of approximately 70 μM[2].
3-Hydroxykynurenine (20-100 μM) induces significant CD4+?T-cell-mediated cell death in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: CD3/CD28 bead-stimulated CD4+ T cells
Concentration: 0, 20, 40, 60, 80, and 100 μM
Incubation Time: 72 hours
Result: Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM.
In Vivo

3-Hydroxykynurenine administration (560 mg/kg IP on a daily basis on days 1 to 7, days 7 to 14, or days 1 to 14) results in significant prolongation of graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (H2d) mice[2]
Dosage: 560 mg/kg
Administration: IP injection
Result: There was significant prolongation of graft survival in all treatment groups in comparison to the controls.
Molecular Weight

224.21

Formula

C10H12N2O4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C(N)CC(C1=CC=CC(O)=C1N)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

1M HCl : 33.33 mg/mL (148.66 mM; ultrasonic and adjust pH to 1 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.33%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M HCl 1 mM 4.4601 mL 22.3005 mL 44.6010 mL 111.5026 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL 22.3005 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL 11.1503 mL
15 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4335 mL
20 mM 0.2230 mL 1.1150 mL 2.2301 mL 5.5751 mL
25 mM 0.1784 mL 0.8920 mL 1.7840 mL 4.4601 mL
30 mM 0.1487 mL 0.7434 mL 1.4867 mL 3.7168 mL
40 mM 0.1115 mL 0.5575 mL 1.1150 mL 2.7876 mL
50 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2301 mL
60 mM 0.0743 mL 0.3717 mL 0.7434 mL 1.8584 mL
80 mM 0.0558 mL 0.2788 mL 0.5575 mL 1.3938 mL
100 mM 0.0446 mL 0.2230 mL 0.4460 mL 1.1150 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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3-Hydroxykynurenine
Cat. No.:
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