2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Arginase Endogenous Metabolite
  4. L-Ornithine

L-Ornithine  (Synonyms: (S)-2,5-Diaminopentanoic acid)

Cat. No.: HY-B1352 Purity: 99.87%
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L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective.

For research use only. We do not sell to patients.

CAS No. : 70-26-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of L-Ornithine:

L-Ornithine Related Antibodies

Top Publications Citing Use of Products

    L-Ornithine purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470.  [Abstract]

    After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), ELISA was utilized to detect proinflammatory factors in macrophages.

    L-Ornithine purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470.  [Abstract]

    After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), Western blot was utilized to measure the expression of proinflammatory factors in macrophages.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    L-Ornithine (0-10 mM) activates the CaSR in a concentration-dependent manner and exerts effects on Ca2+ signaling in HK-2 cells[2].
    L-Ornithine (10 mM) activates TRPC channels mediated Ca2+ entry pathway in HK-2 cells[2].
    L-Ornithine (100 or 300 μM; 24 h) shows the protection against ROS generation in HK-2 cells via ROCE pathway[2].
    L-Ornithine (10 μM) can protect the ROS and oxidative damage in HK-2 cells exposed to H2O2[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Ornithine Related Antibodies
    Molecular Weight

    132.16

    Formula

    C5H12N2O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](CCCN)C(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (378.33 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.5666 mL 37.8329 mL 75.6659 mL
    5 mM 1.5133 mL 7.5666 mL 15.1332 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.87%

    SDS (393 KB)

    COA (243 KB) HNMR (217 KB) RP-HPLC (244 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.5666 mL 37.8329 mL 75.6659 mL 189.1646 mL
    5 mM 1.5133 mL 7.5666 mL 15.1332 mL 37.8329 mL
    10 mM 0.7567 mL 3.7833 mL 7.5666 mL 18.9165 mL
    15 mM 0.5044 mL 2.5222 mL 5.0444 mL 12.6110 mL
    20 mM 0.3783 mL 1.8916 mL 3.7833 mL 9.4582 mL
    25 mM 0.3027 mL 1.5133 mL 3.0266 mL 7.5666 mL
    30 mM 0.2522 mL 1.2611 mL 2.5222 mL 6.3055 mL
    40 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
    50 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
    60 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1527 mL
    80 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3646 mL
    100 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8916 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Ornithine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Ornithine70-26-8(S)-2,5-Diaminopentanoic acidArginaseEndogenous Metaboliteurea cycleremoving excess nitrogennephroprotectiveHK-2Inhibitorinhibitorinhibit

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