Cat. No.: HY-W017018

L-Ornithine hydrochloride

9 Cited Publications

Customer Review

Based on 9 publication(s) in Google Scholar

L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective.

For research use only. We do not sell to patients.

Purity: 99.78%
CAS No.: 3184-13-2
Formula: C₅H₁₃ClN₂O₂
Molecular Weight:168.62

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

L-Ornithine hydrochloride Chemical Structure

CAS No.: 3184-13-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (9)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective^[1]^[2].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	237 μM Compound: 76654	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells	10.5281/zenodo.6782708
HEK293	EC₅₀	237 μM Compound: 76654	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863) Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)	10.5281/zenodo.6782708

In Vitro

L-Ornithine (0-10 mM) activates the CaSR in a concentration-dependent manner and exerts effects on Ca²⁺ signaling in HK-2 cells^[2].
L-Ornithine (10 mM) activates TRPC channels mediated Ca²⁺ entry pathway in HK-2 cells^[2].
L-Ornithine (100 or 300 μM; 24 h) shows the protection against ROS generation in HK-2 cells via ROCE pathway^[2].
L-Ornithine (10 μM) can protect the ROS and oxidative damage in HK-2 cells exposed to H₂O₂^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 3184-13-2
Appearance Solid
Molecular Weight 168.62
Formula C₅H₁₃ClN₂O₂
Color White to off-white
SMILES

NCCC[C@@](N)([H])C(O)=O.Cl
Structure Classification
- Amino acids
Initial Source
- Microorganisms
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (9)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Information Processing in Agriculture

2026 Mar 3.
PLoS Biol

A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans. [Abstract]

2024 Jun 27;22(6):e3002672. PMID: 38935621
Molecules

Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]

2025 Mar 9;30(6):1224. PMID: 40142001
Molecules

Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]

2023 Apr 11;28(8):3375. PMID: 37110608
Amino Acids

Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]

2024 Sep 18;56(1):56. PMID: 39292313
J Cardiovasc Transl Res

LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression. [Abstract]

2025 Jun;18(3):459-470. PMID: 40293654

L-Ornithine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470. [Abstract]

After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), ELISA was utilized to detect proinflammatory factors in macrophages.

L-Ornithine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470. [Abstract]

After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), Western blot was utilized to measure the expression of proinflammatory factors in macrophages.
ChemistrySelect

2023 Jan 12.
bioRxiv

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]

2024 Apr 3:2023.06.02.542933. PMID: 37333363

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (296.52 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.9305 mL

29.6525 mL

59.3050 mL

5 mM

1.1861 mL

5.9305 mL

11.8610 mL

10 mM

0.5930 mL

2.9652 mL

5.9305 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (593.05 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Demura S, et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43. [Content Brief]

[2]. Shin S, et al. l-ornithine activates Ca2+ signaling to exert its protective function on human proximal tubular cells. Cell Signal. 2020 Mar;67:109484. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.9305 mL	29.6525 mL	59.3049 mL	148.2624 mL
	5 mM	1.1861 mL	5.9305 mL	11.8610 mL	29.6525 mL
	10 mM	0.5930 mL	2.9652 mL	5.9305 mL	14.8262 mL
	15 mM	0.3954 mL	1.9768 mL	3.9537 mL	9.8842 mL
	20 mM	0.2965 mL	1.4826 mL	2.9652 mL	7.4131 mL
	25 mM	0.2372 mL	1.1861 mL	2.3722 mL	5.9305 mL
	30 mM	0.1977 mL	0.9884 mL	1.9768 mL	4.9421 mL
	40 mM	0.1483 mL	0.7413 mL	1.4826 mL	3.7066 mL
	50 mM	0.1186 mL	0.5930 mL	1.1861 mL	2.9652 mL
	60 mM	0.0988 mL	0.4942 mL	0.9884 mL	2.4710 mL
	80 mM	0.0741 mL	0.3707 mL	0.7413 mL	1.8533 mL
	100 mM	0.0593 mL	0.2965 mL	0.5930 mL	1.4826 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

L-Ornithine hydrochloride

9 Cited Publications

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L-Ornithine hydrochloride

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Publications Citing Use of MedChemExpress (MCE) L-Ornithine hydrochloride

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (9)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Ornithine hydrochloride Related Classifications

HY-W017018 Related Classifications