1. Anti-infection
    Immunology/Inflammation
    Autophagy
  2. Parasite
    Toll-like Receptor (TLR)
    Autophagy
  3. Desethyl chloroquine diphosphate

Desethyl chloroquine diphosphate 

Cat. No.: HY-135811A
Handling Instructions

Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity.

For research use only. We do not sell to patients.

Desethyl chloroquine diphosphate Chemical Structure

Desethyl chloroquine diphosphate Chemical Structure

CAS No. : 247912-76-1

Size Price Stock Quantity
10 mg USD 1195 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].

IC50 & Target

P. falciparum[1]

In Vivo

Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

487.81

Formula

C₁₆H₂₈ClN₃O₈P₂

CAS No.
SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC.O=P(O)(O)O.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (68.33 mM; Need ultrasonic)

H2O : 20 mg/mL (41.00 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0500 mL 10.2499 mL 20.4998 mL
5 mM 0.4100 mL 2.0500 mL 4.1000 mL
10 mM 0.2050 mL 1.0250 mL 2.0500 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Desethyl chloroquine diphosphateParasiteToll-like Receptor (TLR)AutophagyStereoselectivedesethylmetaboliteChloroquineP. falciparumantiplasmodicInhibitorinhibitorinhibit

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Desethyl chloroquine diphosphate
Cat. No.:
HY-135811A
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