1. Anti-infection
    Immunology/Inflammation
    Autophagy
  2. Parasite
    Toll-like Receptor (TLR)
    Autophagy
  3. Desethyl chloroquine

Desethyl chloroquine 

Cat. No.: HY-135811
Handling Instructions

Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.

For research use only. We do not sell to patients.

Desethyl chloroquine Chemical Structure

Desethyl chloroquine Chemical Structure

CAS No. : 1476-52-4

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Description

Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

In Vitro

P. falciparum[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

291.82

Formula

C₁₆H₂₂ClN₃

CAS No.

1476-52-4

SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Desethyl chloroquineParasiteToll-like Receptor (TLR)AutophagyStereoselectivedesethylmetaboliteChloroquineP. falciparumantiplasmodicInhibitorinhibitorinhibit

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Desethyl chloroquine
Cat. No.:
HY-135811
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