1. Metabolic Enzyme/Protease
  2. Neprilysin
  3. Racecadotril

Racecadotril (Synonyms: Acetorphan)

Cat. No.: HY-17399 Purity: >98.0%
Handling Instructions

Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation.

For research use only. We do not sell to patients.

Racecadotril Chemical Structure

Racecadotril Chemical Structure

CAS No. : 81110-73-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
200 mg USD 60 In-stock
Estimated Time of Arrival: December 31
1 g USD 106 In-stock
Estimated Time of Arrival: December 31
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10 g   Get quote  

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Description

Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uM Target: Enkephalinase Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (259.42 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5942 mL 12.9708 mL 25.9417 mL
5 mM 0.5188 mL 2.5942 mL 5.1883 mL
10 mM 0.2594 mL 1.2971 mL 2.5942 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (6.49 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

385.48

Formula

C₂₁H₂₃NO₄S

CAS No.

81110-73-8

SMILES

O=C(OCC1=CC=CC=C1)CNC(C(CSC(C)=O)CC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Racecadotril
Cat. No.:
HY-17399
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Racecadotril

Cat. No.: HY-17399