1. Metabolic Enzyme/Protease
    Autophagy
  2. Angiotensin-converting Enzyme (ACE)
    Autophagy
  3. Enalaprilat dihydrate

Enalaprilat dihydrate (Synonyms: MK-422)

Cat. No.: HY-B0231 Purity: >98.0%
Handling Instructions

Enalaprilat dihydrate (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

For research use only. We do not sell to patients.

Enalaprilat dihydrate Chemical Structure

Enalaprilat dihydrate Chemical Structure

CAS No. : 84680-54-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 105 In-stock
Estimated Time of Arrival: December 31
500 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Description

Enalaprilat dihydrate (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

IC50 & Target

ACE[1].

In Vitro

Enalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments[1]. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM[2].

In Vivo

Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%)[3].

Clinical Trial
Molecular Weight

384.42

Formula

C₁₈H₂₈N₂O₇

CAS No.

84680-54-6

SMILES

O=C(O)[[email protected]]1N(C([[email protected]](C)N[[email protected]](C(O)=O)CCC2=CC=CC=C2)=O)CCC1.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (260.13 mM)

H2O : 12.5 mg/mL (32.52 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6013 mL 13.0066 mL 26.0132 mL
5 mM 0.5203 mL 2.6013 mL 5.2026 mL
10 mM 0.2601 mL 1.3007 mL 2.6013 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Enalaprilat dihydrateMK-422MK422MK 422Angiotensin-converting Enzyme (ACE)AutophagyInhibitorinhibitorinhibit

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Enalaprilat dihydrate
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