Cat. No.: HY-N2013

Aristolactam I

(Synonyms: Aristololactam; Aristolactam)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.

For research use only. We do not sell to patients.

Purity: 99.44%
CAS No.: 13395-02-3
Formula: C₁₇H₁₁NO₄
Molecular Weight:293.27

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Aristolactam I Chemical Structure

CAS No.: 13395-02-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All TGF-beta/Smad Isoforms :

Smad1
Smad3

In Vitro

Aristolactam I (0-40 μM; 21-48 h) inhibits cell migration and invasion through regulation of Twist1 in MDA-MB-231 breast cancer cells^[1].
Aristolactam I (2.5-10 μM; 48 h) enhances the tendency of HK-2 cells to transform from epithelial cells to fibroblast-like cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

MDA-MB-231
Concentration:

0 μM, 40 μM
Incubation Time:

48 h
Result:

Upregulated mRNA expression of CDH1 and downregulated CDH2 mRNA expression.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231
Concentration:

0 μM, 20 μM, 40 μM
Incubation Time:

48 h
Result:

Increased protein expression of E-cadherin, decreased N-cadherin and Twist1 protein expression.

In Vivo

Aristolactam I (2.25-9 mg/kg; i.p.; 5 days) induces nephrotoxicity in Sprague-Dawley rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (weighing 200-250 g)^[5]
Dosage:

2.25, 4.5, 9 mg/kg
Administration:

Intraperitoneal injection, 5 days
Result:

Significantly increased 24-hour urine volume.
Showed a stronger diuretic effect than Aristolochic acid I.
Caused early damage to the renal proximal tubules, with a stronger renal injury potential than Aristolochic acid I.
Inhibited the expression of renal AQP1, AQP2, and AQP4.

Chemical Information

CAS No. 13395-02-3
Appearance Solid
Molecular Weight 293.27
Formula C₁₇H₁₁NO₄
Color Light yellow to yellow
SMILES

O=C1NC2=C(C3=C4C(C(OC)=CC=C4)=C2)C1=CC5=C3OCO5
Synonyms

Aristololactam; Aristolactam
Structure Classification
- Others
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Toxicol Lett

Mitochondrial uptake of aristolactam I plays a critical role in its toxicity. [Abstract]

2024 Apr:394:76-91. PMID: 38428544

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (42.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4098 mL

17.0491 mL

34.0983 mL

5 mM

0.6820 mL

3.4098 mL

6.8197 mL

10 mM

0.3410 mL

1.7049 mL

3.4098 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee S, et al. Aristolactam I inhibits cell migration and invasion through regulation of Twist1 in MDA‐MB‐231 breast cancer cells. Bulletin of the Korean Chemical Society, 2022, 43(9): 1148-1151.

[2]. Zhang X, et al. An investigation on nephrotoxicity of Aristolactam I induced epithelial-mesenchymal transition on HK-2 cells. Toxicon. 2021 Oct 15;201:21-26. [Content Brief]

[3]. Li J , et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7. [Content Brief]

[4]. Zhou Y , et al. Mitochondrial uptake of aristolactam I plays a critical role in its toxicity. Toxicol Lett. 2024 Apr;394:76-91. [Content Brief]

[5]. Li J, et al. Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. Nephron. 2016;133(3):213-21. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4098 mL	17.0491 mL	34.0983 mL	85.2457 mL
	5 mM	0.6820 mL	3.4098 mL	6.8197 mL	17.0491 mL
	10 mM	0.3410 mL	1.7049 mL	3.4098 mL	8.5246 mL
	15 mM	0.2273 mL	1.1366 mL	2.2732 mL	5.6830 mL
	20 mM	0.1705 mL	0.8525 mL	1.7049 mL	4.2623 mL
	25 mM	0.1364 mL	0.6820 mL	1.3639 mL	3.4098 mL
	30 mM	0.1137 mL	0.5683 mL	1.1366 mL	2.8415 mL
	40 mM	0.0852 mL	0.4262 mL	0.8525 mL	2.1311 mL

Keywords

Aristolactam I

1 Cited Publications

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Aristolactam I

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Publications Citing Use of MedChemExpress (MCE) Aristolactam I

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Aristolactam I Related Classifications

Cat. No.: HY-N2013