Desacetylcephapirin sodium  (Synonyms: Deacetylcephapirin sodium)

Desacetylcephapirin sodium (Deacetylcephapirin sodium) is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen^[1][2].

Antibacterial^[2]

Desacetylcephapirin sodium exhibits inhibitory activity on Streptococcus dysgalactiae, with MIC₅₀s both of 0.25 µg/mL for clinical and subclinical bacterial strain^[2].
Desacetylcephapirin sodium exhibits inhibitory activity on coagulase-negative staphylococci mastitis pathogen, with MIC₅₀s both of 0.12 µg/mL for clinical and subclinical bacterial strain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

403.41

C₁₅H₁₄N₃NaO₅S₂

104557-24-6

Solid

Off-white to light yellow

O=C(C(N12)=C(CO)CS[C@]2([H])[C@H](NC(CSC3=CC=NC=C3)=O)C1=O)O[Na]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. B. E. Cabana, et al. Comparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans. Antimicrob Agents Chemother. 1976 Aug; 10(2): 307-317.  [Content Brief]

  [2]. Cristina S Cortinhas, et al. Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. Am J Vet Res. 2013 May;74(5):683-90.  [Content Brief]