Leucomalachite green-d5
Based on 1 Customer Validation
Leucomalachite green-d5 is the deuterated derivative of Leucomalachite green (HY-D0300). Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 947601-82-3
- Formula: C23H21D5N2
- Molecular Weight:335.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 947601-82-3
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Unlabeled Cas 129-73-7
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Appearance Solid
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Molecular Weight 335.50
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Formula C23H21D5N2
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SMILES
CN(C)C(C=C1)=CC=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C3=CC=C(C=C3)N(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (298.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-236. [Content Brief]
[2]. Ya-hui Li, et al. Development of a group selective molecularly imprinted polymers based solid phase extraction of malachite green from fish water and fish feed samples. Anal Chim Acta. 2008 Aug 29;624(2):317-25. [Content Brief]
[3]. Stammati A, et al. Effects of malachite green (MG) and its major metabolite, leucomalachite green (LMG), in two human cell lines. Toxicol In Vitro. 2005 Oct;19(7):853-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9806 mL | 14.9031 mL | 29.8063 mL | 74.5156 mL |
| 5 mM | 0.5961 mL | 2.9806 mL | 5.9613 mL | 14.9031 mL | |
| 10 mM | 0.2981 mL | 1.4903 mL | 2.9806 mL | 7.4516 mL | |
| 15 mM | 0.1987 mL | 0.9935 mL | 1.9871 mL | 4.9677 mL | |
| 20 mM | 0.1490 mL | 0.7452 mL | 1.4903 mL | 3.7258 mL | |
| 25 mM | 0.1192 mL | 0.5961 mL | 1.1923 mL | 2.9806 mL | |
| 30 mM | 0.0994 mL | 0.4968 mL | 0.9935 mL | 2.4839 mL | |
| 40 mM | 0.0745 mL | 0.3726 mL | 0.7452 mL | 1.8629 mL | |
| 50 mM | 0.0596 mL | 0.2981 mL | 0.5961 mL | 1.4903 mL | |
| 60 mM | 0.0497 mL | 0.2484 mL | 0.4968 mL | 1.2419 mL | |
| 80 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.9314 mL | |
| 100 mM | 0.0298 mL | 0.1490 mL | 0.2981 mL | 0.7452 mL |
Leucomalachite green-d5 Related Classifications
HY-D0300S Related Classifications
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