2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 21-Desacetyldeflazacort

21-Desacetyldeflazacort  (Synonyms: 21-desDFZ)

Cat. No.: HY-100085 Purity: 99.23%
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21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.

For research use only. We do not sell to patients.

21-Desacetyldeflazacort Chemical Structure

21-Desacetyldeflazacort Chemical Structure

CAS No. : 13649-57-5

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5 mg USD 150 In-stock
10 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

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21-Desacetyldeflazacort Related Antibodies

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Description

21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration[1].

Molecular Weight

399.48

Formula

C23H29NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(CC4)=CC(C=C5)=O)C)([H])[C@H](C3)O)([H])C[C@@]1([H])OC(C)=N2)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (625.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5033 mL 12.5163 mL 25.0325 mL
5 mM 0.5007 mL 2.5033 mL 5.0065 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5033 mL 12.5163 mL 25.0325 mL 62.5814 mL
5 mM 0.5007 mL 2.5033 mL 5.0065 mL 12.5163 mL
10 mM 0.2503 mL 1.2516 mL 2.5033 mL 6.2581 mL
15 mM 0.1669 mL 0.8344 mL 1.6688 mL 4.1721 mL
20 mM 0.1252 mL 0.6258 mL 1.2516 mL 3.1291 mL
25 mM 0.1001 mL 0.5007 mL 1.0013 mL 2.5033 mL
30 mM 0.0834 mL 0.4172 mL 0.8344 mL 2.0860 mL
40 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5645 mL
50 mM 0.0501 mL 0.2503 mL 0.5007 mL 1.2516 mL
60 mM 0.0417 mL 0.2086 mL 0.4172 mL 1.0430 mL
80 mM 0.0313 mL 0.1565 mL 0.3129 mL 0.7823 mL
100 mM 0.0250 mL 0.1252 mL 0.2503 mL 0.6258 mL
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21-Desacetyldeflazacort Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

21-Desacetyldeflazacort13649-57-521-desDFZDrug Metaboliteanti-inflammatoryimmunosuppressantesteraseInhibitorinhibitorinhibit

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