Lopinavir Metabolite M-1
Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro.
For research use only. We do not sell to patients.
- CAS No.: 192725-39-6
- Formula: C37H46N4O6
- Molecular Weight:642.78
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.7 pM (HIV Protease)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | EC50 |
0.14 μM
Compound: 1j
|
Tested for cytopathic effect of HIVIIIB in MT-4 cells in presence of 50% human serum
Tested for cytopathic effect of HIVIIIB in MT-4 cells in presence of 50% human serum
|
[PMID: 15109669] |
| MT4 | EC50 |
1.413 μM
Compound: M-1
|
Antiviral activity against HIV in presence of 50% human serum in MT-4 cell was determined
Antiviral activity against HIV in presence of 50% human serum in MT-4 cell was determined
|
[PMID: 11378352] |
Chemical Information
-
CAS No. 192725-39-6
-
Molecular Weight 642.78
-
Formula C37H46N4O6
-
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C[C@H](O)[C@@H](NC(COC2=C(C)C=CC=C2C)=O)CC3=CC=CC=C3)[C@H](C(C)C)N(C(N4)=O)CCC4=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3. [Content Brief]
[2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lopinavir Metabolite M-1 Related Classifications
HY-136703 Related Classifications
Powered by Bioz