2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Gemcitabine triphosphate trisodium

Gemcitabine triphosphate trisodium  (Synonyms: dFdCTP trisodium)

Cat. No.: HY-17026E Purity: 98.09%
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Gemcitabine triphosphate (trisodium) is one of the two nucleoside metabolites of Gemcitabine (HY-17026) in cells. The other is active diphosphate (dFdDTP). Gemcitabine triphosphate can be used as a standard in radio-labeled probe imaging studies, to identify tumors sensitive to Gemcitabine, and to evaluate Gemcitabine uptake and retention by cells.

For research use only. We do not sell to patients.

Gemcitabine triphosphate trisodium Chemical Structure

Gemcitabine triphosphate trisodium Chemical Structure

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1 mg USD 250 In-stock
5 mg USD 750 In-stock
10 mg USD 1200 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Gemcitabine triphosphate (trisodium) is one of the two nucleoside metabolites of Gemcitabine (HY-17026) in cells. The other is active diphosphate (dFdDTP). Gemcitabine triphosphate can be used as a standard in radio-labeled probe imaging studies, to identify tumors sensitive to Gemcitabine, and to evaluate Gemcitabine uptake and retention by cells[1].

Molecular Weight

569.08

Formula

C9H11F2N3Na3O13P3
Appearance

Solid

Color

White to off-white

SMILES

NC(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)=NC1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (219.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7572 mL 8.7861 mL 17.5722 mL
5 mM 0.3514 mL 1.7572 mL 3.5144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7572 mL 8.7861 mL 17.5722 mL 43.9306 mL
5 mM 0.3514 mL 1.7572 mL 3.5144 mL 8.7861 mL
10 mM 0.1757 mL 0.8786 mL 1.7572 mL 4.3931 mL
15 mM 0.1171 mL 0.5857 mL 1.1715 mL 2.9287 mL
20 mM 0.0879 mL 0.4393 mL 0.8786 mL 2.1965 mL
25 mM 0.0703 mL 0.3514 mL 0.7029 mL 1.7572 mL
30 mM 0.0586 mL 0.2929 mL 0.5857 mL 1.4644 mL
40 mM 0.0439 mL 0.2197 mL 0.4393 mL 1.0983 mL
50 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8786 mL
60 mM 0.0293 mL 0.1464 mL 0.2929 mL 0.7322 mL
80 mM 0.0220 mL 0.1098 mL 0.2197 mL 0.5491 mL
100 mM 0.0176 mL 0.0879 mL 0.1757 mL 0.4393 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gemcitabine triphosphate trisodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemcitabine triphosphate trisodiumdFdCTP trisodiumEndogenous MetaboliteNucleoside MetaboliteInhibitorinhibitorinhibit

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