1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Hydroxy bosentan

Hydroxy bosentan (Synonyms: Ro 48-5033)

Cat. No.: HY-121385
Handling Instructions

Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.

For research use only. We do not sell to patients.

Hydroxy bosentan Chemical Structure

Hydroxy bosentan Chemical Structure

CAS No. : 253688-60-7

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Description

Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

567.61

Formula

C₂₇H₂₉N₅O₇S

CAS No.

253688-60-7

SMILES

COC1=CC=CC=C1OC2=C(N=C(N=C2OCCO)C3=NC=CC=N3)NS(C4=CC=C(C=C4)C(CO)(C)C)(=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Hydroxy bosentanRo 48-5033Endogenous MetaboliteprimarymetaboliteBosentanBOScytochromeP450liverpharmacologicallyInhibitorinhibitorinhibit

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Hydroxy bosentan
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HY-121385
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