2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Pitavastatin lactone

Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes.

For research use only. We do not sell to patients.

Pitavastatin lactone Chemical Structure

Pitavastatin lactone Chemical Structure

CAS No. : 141750-63-2

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Based on 1 publication(s) in Google Scholar

Pitavastatin lactone Related Antibodies

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Description

Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].

Molecular Weight

403.45

Formula

C25H22FNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C[C@H](O)C[C@@H](/C=C/C2=C(C3=CC=C(F)C=C3)C4=CC=CC=C4N=C2C5CC5)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4786 mL 12.3931 mL 24.7862 mL
5 mM 0.4957 mL 2.4786 mL 4.9572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4786 mL 12.3931 mL 24.7862 mL 61.9655 mL
5 mM 0.4957 mL 2.4786 mL 4.9572 mL 12.3931 mL
10 mM 0.2479 mL 1.2393 mL 2.4786 mL 6.1966 mL
15 mM 0.1652 mL 0.8262 mL 1.6524 mL 4.1310 mL
20 mM 0.1239 mL 0.6197 mL 1.2393 mL 3.0983 mL
25 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4786 mL
30 mM 0.0826 mL 0.4131 mL 0.8262 mL 2.0655 mL
40 mM 0.0620 mL 0.3098 mL 0.6197 mL 1.5491 mL
50 mM 0.0496 mL 0.2479 mL 0.4957 mL 1.2393 mL
60 mM 0.0413 mL 0.2066 mL 0.4131 mL 1.0328 mL
80 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7746 mL
100 mM 0.0248 mL 0.1239 mL 0.2479 mL 0.6197 mL
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Pitavastatin lactone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pitavastatin lactone141750-63-2Drug MetabolitemetabolitepitavastatinhumansHMG-CoAhepaticmicrosomesInhibitorinhibitorinhibit

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