1. Metabolic Enzyme/Protease
    Autophagy
    Apoptosis
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Mitophagy
    Apoptosis
  3. Pitavastatin

Pitavastatin (Synonyms: NK-104)

Cat. No.: HY-B0144A
Handling Instructions

Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

For research use only. We do not sell to patients.

Pitavastatin Chemical Structure

Pitavastatin Chemical Structure

CAS No. : 147511-69-1

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Description

Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

In Vitro

Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50=0.4-5 μM) or as spheroids (IC50 = 0.6-4 μM)[4]
Pitavastatin (1 μM; 48 hours ) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells[4].
Pitavastatin (1 μM, 48 hours) caused PARP cleavage in Ovcar-8 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Ovcar-8 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: Induced PARP cleavage.
In Vivo

Pitavastatin (59 mg/kg; p.o.; twice daily for 28 days) caused significant tumour regression[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4 week old female NCR Nu/Nu female mice (bearing Ovcar-4 tumours)[4]
Dosage: 59 mg/kg
Administration: p.o.; twice daily for 28 days
Result: Caused significant tumour regression.
Clinical Trial
Molecular Weight

421.46

Formula

C₂₅H₂₄FNO₄

CAS No.

147511-69-1

SMILES

O=C(O)C[[email protected]](O)C[[email protected]](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PitavastatinNK-104NK104NK 104HMG-CoA Reductase (HMGCR)AutophagyMitophagyApoptosisMitochondrial AutophagyInhibitorinhibitorinhibit

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