Pitavastatin sodium
Based on 6 publication(s) in Google Scholar
Pitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 574705-92-3
- 分子式: C25H23FNNaO4
- 分子量:443.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Pitavastatin sodium
More- Cancer Res. 2026 Jul 15;86(14):3436-3458. [Abstract]
- Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]
- Sci Data. 2024 Sep 19;11(1):1024. [Abstract]
- Bioorg Chem. 2024 Jun:147:107369. [Abstract]
- Acta Biochim Biophys Sin (Shanghai). 2024 Apr 25;56(4):621-633. [Abstract]
- Research Square Preprint. 2024 Apr 9.
Customer Validation & Images
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Microbiological Assay
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Microbiological Assay
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Microbiological Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
生物活性
HMG-CoA Reductase[1]
Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50=0.4-5 μM) or as spheroids (IC50 = 0.6-4 μM)[4].
Pitavastatin (1 μM; 48 hours) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells[4].
Pitavastatin (1 μM, 48 hours) causes PARP cleavage in Ovcar-8 cells[4].
Pitavastatin (0.1 and 1 μM; 1 h, then cells incubate with TNF-α for 6 h) increases the expression of ICAM-1 mRNA through suppressing NF-κB pathway in TNF-α-stimulated human saphenous vein endothelial cells[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ovcar-8 cells
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Concentration:1 μM
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Incubation Time:48 hours
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Result:Induced PARP cleavage.
Pitavastatin (0.1 mg/kg; p.o; daily for 12 weeks) retards the progression of atherosclerosis formation and improves NO bioavailability by eNOS up-regulation and decrease of O2- in diet induced severe hyperlipidemia rabbit model[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4 week old female NCR Nu/Nu female mice (bearing Ovcar-4 tumours)[4]
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Dosage:59 mg/kg
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Administration:p.o.; twice daily for 28 days
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Result:Caused significant tumour regression.
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Animal Model:Female New Zealand white rabbits (diet induced severe hyperlipidemia)[7]
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Dosage:0.1 mg/kg
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Administration:p.o; daily for 12 weeks
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Result:Retarded the progression of atherosclerosis formation and improved NO bioavailability by eNOS up-regulation and decrease of O2-.
化学情報
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CAS 番号 574705-92-3
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分子量 443.44
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分子式 C25H23FNNaO4
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SMILES
O=C(O[Na])C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(C=C2)F)C3=C(C=CC=C3)N=C1C4CC4
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別名
NK-104 sodium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Cancer Res
TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma. [Abstract]2026 Jul 15;86(14):3436-3458. PMID: 41974002 -
Antioxidants (Basel)
Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species. [Abstract]2024 May 29;13(6):667. PMID: 38929106
Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]
Pitavastatin Calcium (0.5-1 μM) makes FLC fungicidal.
Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]
PIT (0-25 μM) confers fungicidal properties to voriconazole, ketoconazole, itraconazole, and miconazole.
Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667. [Abstract]
MIC assays and spotting assays show that erg11△/erg11△ was significantly sensitive to PIT (0-100 μM) compared to the wild-type strain.
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Sci Data
High-throughput drug screening identifies novel therapeutics for Low Grade Serous Ovarian Carcinoma. [Abstract]2024 Sep 19;11(1):1024. PMID: 39300112 -
Bioorg Chem
Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress. [Abstract]2024 Jun:147:107369. PMID: 38640721
Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2024 Jun:147:107369. [Abstract]
Oil red O staining and quantification of zebrafish liver after treatment with DTPP and Pitavastatin Calcium. Day1 of DTPP treatment.
Pitavastatin sodium purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2024 Jun:147:107369. [Abstract]
Oil red O staining and quantification of zebrafish liver after treatment with DTPP and Pitavastatin Calcium. Day3 of DTPP treatment.
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Acta Biochim Biophys Sin (Shanghai)
Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis. [Abstract]2024 Apr 25;56(4):621-633. PMID: 38516704 -
純度とドキュメンテーション
参考文献
[1]. Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44. [Content Brief]
[2]. Katsuki S, et al. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 2014 Feb 25;129(8):896-906. [Content Brief]
[3]. Tajiri K, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24. [Content Brief]
[4]. Hamano T, et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiol Aging. 2012 Oct;33(10):2306-20. [Content Brief]
[5]. de Wolf E, et al.Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer.Sci Rep. 2017 Jul 14;7(1):5410. [Content Brief]
[6]. Demir B, et al. The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture. Cardiovasc Ther. 2019 May 2;2019:2549432. [Content Brief]
[7]. Hayashi T, et al. A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits. Atherosclerosis. 2004 Oct;176(2):255-63. [Content Brief]
[8]. Sahebkar A, et al. A comprehensive review on the lipid and pleiotropic effects of pitavastatin. Prog Lipid Res. 2021 Nov;84:101127. [Content Brief]
Calculators
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Pitavastatin sodium 関連分類
HY-B0144B 関連分類
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