2. Metabolic Enzyme/Protease Autophagy Apoptosis
  3. HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis
  4. Pitavastatin Calcium

Pitavastatin Calcium  (Synonyms: NK-104 hemicalcium; Pitavastatin hemicalcium)

Cat. No.: HY-B0144 Purity: 99.89%
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Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.

For research use only. We do not sell to patients.

CAS No. : 147526-32-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Pitavastatin Calcium:

Pitavastatin Calcium Related Antibodies

Top Publications Citing Use of Products

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667.  [Abstract]

    Pitavastatin Calcium (0.5-1 μM) makes FLC fungicidal.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667.  [Abstract]

    PIT (0-25 μM) confers fungicidal properties to voriconazole, ketoconazole, itraconazole, and miconazole.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 29;13(6):667.  [Abstract]

    MIC assays and spotting assays show that erg11△/erg11△ was significantly sensitive to PIT (0-100 μM) compared to the wild-type strain.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2024 Jun:147:107369.  [Abstract]

    Oil red O staining and quantification of zebrafish liver after treatment with DTPP and Pitavastatin Calcium. Day1 of DTPP treatment.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2024 Jun:147:107369.  [Abstract]

    Oil red O staining and quantification of zebrafish liver after treatment with DTPP and Pitavastatin Calcium. Day3 of DTPP treatment.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2024 Apr 25;56(4):621-633.  [Abstract]

    Typical oil red O staining images showing the alleviation of lipid accumulation by LMY and Pitavastatin (NK-104) (2% (w/w); dietary administration) in larval zebrafish. The number of zebrafish larvae involved in each experimental group is indicated in the top left corner of each image.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Proteomics. 2023 Aug;23(16):e2300041.  [Abstract]

    IC50 values of ERK, S6K inhibitors and statins in parental and resistant cells. (The treatment duration for compounds such as Pitavastatin was 72 h.)

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Proteomics. 2023 Aug;23(16):e2300041.  [Abstract]

    Western blot against cav-1 after treatment of resistant cells with statins at IC50s for 48 h. Stained MIA PaCa-2 cells were treated with 1 µM GDC-0994, 30 µM DG2, 1.56 µM atorvastatin, 1.56 µM fluvastatin or 0.195 µM Pitavastatin.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2020 May;10(5):850-860.  [Abstract]

    Pharmacokinetic parameters of Pitavastatin (5 mg/kg; single dose) after oral administration.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2020 May;10(5):850-860.  [Abstract]

    Pharmacokinetics of Pitavastatin (5 mg/kg; p.o.; single dose) in WT and KO rats. The concentrations of Pitavastatin were determined by LC–MS/MS.

    Pitavastatin Calcium purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2019 Nov:169:113612.  [Abstract]

    Uptake ability of Pitavastatin (a human OATP1B1/1B3 substrate，0.1-10 μM; 1 h) by the control and rSlco1b2 overexpression cells. The rate was expressed as the relative intracellular substrate concentration (substrate/internal standard MS/MS response ratio).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects[1][2][3][8].

    IC50 & Target

    HMG-CoA Reductase[1]
    In Vitro

    Pitavastatin Calcium inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC50 = 0.4-5 μM) or as spheroids (IC50=0.6-4 μM)[3].
    Pitavastatin Calcium (1 μM; 48 hours ) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in Ovcar-8 cells and Ovcar-3 cells[3].
    Pitavastatin (1 μM, 48 hours) causes PARP cleavage in Ovcar-8 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Pitavastatin Calcium Related Antibodies

    Western Blot Analysis[3]

    Cell Line: Ovcar-8 cells
    Concentration: 1 μM
    Incubation Time: 48 hours
    Result: Induced PARP cleavage.
    In Vivo

    Pitavastatin Calcium (59 mg/kg; p.o.; twice daily for 28 days) causes significant tumour regression[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 4 week old female NCR Nu/Nu female mice (bearing Ovcar-4 tumours)[3]
    Dosage: 59 mg/kg
    Administration: p.o.; twice daily for 28 days
    Result: Caused significant tumour regression.
    Clinical Trial
    Molecular Weight

    440.49

    Formula

    C25H23Ca0.5FNO4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([O-])C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4.[0.5Ca2+]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (113.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2702 mL 11.3510 mL 22.7020 mL
    5 mM 0.4540 mL 2.2702 mL 4.5404 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.89%

    SDS (394 KB)

    COA (252 KB) HNMR (138 KB) RP-HPLC (246 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2702 mL 11.3510 mL 22.7020 mL 56.7550 mL
    5 mM 0.4540 mL 2.2702 mL 4.5404 mL 11.3510 mL
    10 mM 0.2270 mL 1.1351 mL 2.2702 mL 5.6755 mL
    15 mM 0.1513 mL 0.7567 mL 1.5135 mL 3.7837 mL
    20 mM 0.1135 mL 0.5675 mL 1.1351 mL 2.8377 mL
    25 mM 0.0908 mL 0.4540 mL 0.9081 mL 2.2702 mL
    30 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.8918 mL
    40 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.4189 mL
    50 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1351 mL
    60 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9459 mL
    80 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7094 mL
    100 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5675 mL
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    Pitavastatin Calcium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pitavastatin147526-32-7NK-104 hemicalcium Pitavastatin hemicalciumHMG-CoA Reductase (HMGCR)AutophagyMitophagyApoptosisMitochondrial AutophagyInhibitorinhibitorinhibit

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