1. Metabolic Enzyme/Protease
    Autophagy
    Membrane Transporter/Ion Channel
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Potassium Channel
  3. Rosuvastatin Calcium

Rosuvastatin Calcium (Synonyms: Rosuvastatin hemicalcium; ZD 4522 Calcium)

Cat. No.: HY-17504 Purity: 99.94%
Handling Instructions

Rosuvastatin Calcium (Rosuvastatin hemicalcium) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

For research use only. We do not sell to patients.

Rosuvastatin Calcium Chemical Structure

Rosuvastatin Calcium Chemical Structure

CAS No. : 147098-20-2

Size Price Stock Quantity
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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 92 In-stock
Estimated Time of Arrival: December 31
100 mg USD 119 In-stock
Estimated Time of Arrival: December 31
200 mg USD 158 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 7 publication(s) in Google Scholar

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Description

Rosuvastatin Calcium (Rosuvastatin hemicalcium) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin Calcium potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3].

IC50 & Target

IC50: 11 nM (HMG-CoA) and 195 nM (hERG)[1,2]

In Vivo

Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201 ± 1 to 210 ± 2 ms.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

500.57

Formula

C22H27Ca0.5FN3O6S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (49.94 mM; Need ultrasonic)

H2O : 1 mg/mL (2.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9977 mL 9.9886 mL 19.9772 mL
5 mM 0.3995 mL 1.9977 mL 3.9954 mL
10 mM 0.1998 mL 0.9989 mL 1.9977 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.94%

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Product Name:
Rosuvastatin Calcium
Cat. No.:
HY-17504
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