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Rosuvastatin

(Synonyms: ZD 4522)
27 Cited Publications
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Based on 27 publication(s) in Google Scholar

Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

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  • Purity: 99.67%
  • CAS No.: 287714-41-4
  • Formula: C22H28FN3O6S
  • Molecular Weight:481.54
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Rosuvastatin Chemical Structure
    Rosuvastatin Chemical Structure
  • Experimental Validation Results for Rosuvastatin
  • Experimental Validation Results for Rosuvastatin
  • Experimental Validation Results for Rosuvastatin
  • Experimental Validation Results for Rosuvastatin
  • Experimental Validation Results for Rosuvastatin
CAS No.: 287714-41-4
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Rosuvastatin Chemical Structure
    Rosuvastatin Chemical Structure
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    Rosuvastatin purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2024 Aug 31;5(9):e681. [Abstract]

    Customer Validation
     Chemerin levels in the medium of HepG2 cells cultured for 48 h, in the absence (control) or presence of atorvastatin, evolocumab, or Rosuvastatin, were measured.

  • 1/16

    Rosuvastatin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 5:e2403451. [Abstract]

    Customer Validation
     Western blotting of PAQR9 in mouse primary hepatocytes under the treatment of DMSO, simvastatin (Sim), atorvastatin (Ator), and rosuvastatin (Rosu) (10 μM; 24–48 h) was performed.

  • 1/16

    Rosuvastatin purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 May 29;10(1):263. [Abstract]

    Customer Validation
     Rosuvastatin calcium (5 mg/kg i.p.) was administered. Images of the wound area in the rosuvastatin calcium-treated group and the control group were captured.

  • 1/16

    Rosuvastatin purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 May 29;10(1):263. [Abstract]

    Customer Validation
     Rosuvastatin calcium (5 mg/kg i.p.) was administered. The free cholesterol level of skin tissue after rosuvastatin calcium treatment for 12 days was measured. Each experiment was replicated at least thrice and representative images were shown.

  • 1/16

    Rosuvastatin purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Jul;44(7):1416-1428. [Abstract]

    Customer Validation
     Rosuvastatin calcium (10 mg/kg body weight every second day, n = 5) was administered. The body weights of control and bavachin-treated mice were measured weekly from weeks 1 to 20.

  • Rosuvastatin