1. Metabolic Enzyme/Protease
    Autophagy
    Membrane Transporter/Ion Channel
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Potassium Channel
  3. Rosuvastatin

Rosuvastatin (Synonyms: ZD 4522)

Cat. No.: HY-17504A
Handling Instructions

Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

For research use only. We do not sell to patients.

Rosuvastatin Chemical Structure

Rosuvastatin Chemical Structure

CAS No. : 287714-41-4

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Description

Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3].

IC50 & Target

IC50: 11 nM (HMG-CoA) and 195 nM (hERG)[1,2]

In Vivo

Rosuvastatin (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[2].
Rosuvastatin (20 mg/kg/day) administration for 2 weeks, significantly reduces very low-density lipoproteins (VLDL) in diabetes mellitus rats induced by Streptozocin[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

481.54

Formula

C₂₂H₂₈FN₃O₆S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Rosuvastatin
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HY-17504A
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