Cat. No.: HY-B0165A

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Pravastatin sodium

(Synonyms: CS-514 sodium)

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

For research use only. We do not sell to patients.

Purity: 99.02%
CAS No.: 81131-70-6
Formula: C₂₃H₃₅NaO₇
Molecular Weight:446.51

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Pravastatin sodium Chemical Structure

CAS No.: 81131-70-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

IC₅₀ & Target

HMG-CoA reductase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	0.1 μM Compound: 1c	Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes. Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.	[PMID: 2231594]
Hepatocyte	IC₅₀	100 nM Compound: 2	The compound was tested for inhibition of Cholesterol synthesis from [14C]- Acetate in hepatocytes of rats. The compound was tested for inhibition of Cholesterol synthesis from [14C]- Acetate in hepatocytes of rats.	[PMID: 1895299]
HepG2	IC₅₀	>200 μM Compound: Pravastatin sodium	Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR	[PMID: 20457823]
HepG2	IC₅₀	1.37 μM Compound: Pravastatin sodium	In vitro HMG-CoA reductase inhibitory activity to inhibit cellular steroidgenesis in Hep G2 cells (human hepatoma cell line) In vitro HMG-CoA reductase inhibitory activity to inhibit cellular steroidgenesis in Hep G2 cells (human hepatoma cell line)	[PMID: 11392538]

In Vitro

Pravastatin (CS-514) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 81131-70-6
Appearance Solid
Molecular Weight 446.51
Formula C₂₃H₃₅NaO₇
Color Off-white to Pale purple
SMILES

O[C@@H](C[C@@H](O)CC(O[Na])=O)CC[C@@H]([C@H](C=C1)C)[C@@](C1=C[C@@H](O)C2)([H])[C@H]2OC([C@@H](C)CC)=O
Synonyms

CS-514 sodium
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Penicillium Citrinum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (8)

All Cell Proliferation/Viability AssayRT-PCRCell Imaging/Staining

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Journal Impact Factor

Cell Syst

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]

2018 Apr 25;6(4):424-443.e7. PMID: 29655704
Phytother Res

Syringin Protects Against Doxorubicin-Induced Cardiotoxicity via Apelinr-Dependent Activation of the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Antioxidant Pathway. [Abstract]

2026 Mar 26. PMID: 41883153
Front Cell Dev Biol

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis. [Abstract]

2022 Mar 3;10:806081. PMID: 35309902
Front Cell Dev Biol

Construction of Escherichia coli Whole-Cell Biosensors for Statin Efficacy and Production Test. [Abstract]

2020 May 28;8:404. PMID: 32671060
Chin J Integr Med

Treg Immunomodulation Contributes to the Anti-atherosclerotic Effects of Huxin Formula in ApoE-/- Mice. [Abstract]

2024 May 16. PMID: 38753277
FEBS Open Bio

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis. [Abstract]

2025 Aug 8. PMID: 40781787

Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Growth inhibition following statin treatment of THP‐1 cells. To assess cell proliferation, 1 × 10⁴ cells were seeded in a six‐well plate and cultured with DMSO or Pravastatin (2 or 4 μM). Trypan blue dye exclusion assays were performed after 6 days of treatment (n = 4).

Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Relative mRNA expression levels of KLF4 and DPYSL2A in THP‐1 cells treated by Pravastatin (2 or 4 μM). Total RNA was then extracted and analyzed by RT‐qPCR. Values were normalized to the GAPDH expression levels (n = 3).

Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Cell surface expression levels of CD11b and CD14 in THP‐1 cells treated Pravastatin (2 or 4 μM) (n = 3).

Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Morphological changes in THP‐1 cells treated with DMSO or Pravastatin (4 μM) for 6 days.

Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Apoptosis of THP‐1 cells treated Pravastatin (2 or 4 μM). The annexin V‐positive cells were scored using flow cytometric analysis (n = 3).
bioRxiv

2026 May 22.
Research Square Preprint

2022 Feb.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (223.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (111.98 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2396 mL

11.1980 mL

22.3959 mL

5 mM

0.4479 mL

2.2396 mL

4.4792 mL

10 mM

0.2240 mL

1.1198 mL

2.2396 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (223.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.2396 mL	11.1980 mL	22.3959 mL	55.9898 mL
	5 mM	0.4479 mL	2.2396 mL	4.4792 mL	11.1980 mL
	10 mM	0.2240 mL	1.1198 mL	2.2396 mL	5.5990 mL
	15 mM	0.1493 mL	0.7465 mL	1.4931 mL	3.7327 mL
	20 mM	0.1120 mL	0.5599 mL	1.1198 mL	2.7995 mL
	25 mM	0.0896 mL	0.4479 mL	0.8958 mL	2.2396 mL
	30 mM	0.0747 mL	0.3733 mL	0.7465 mL	1.8663 mL
	40 mM	0.0560 mL	0.2799 mL	0.5599 mL	1.3997 mL
	50 mM	0.0448 mL	0.2240 mL	0.4479 mL	1.1198 mL
	60 mM	0.0373 mL	0.1866 mL	0.3733 mL	0.9332 mL
	80 mM	0.0280 mL	0.1400 mL	0.2799 mL	0.6999 mL
	100 mM	0.0224 mL	0.1120 mL	0.2240 mL	0.5599 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Pravastatin sodium

8 Cited Publications

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Pravastatin sodium

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Publications Citing Use of MedChemExpress (MCE) Pravastatin sodium

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Pravastatin sodium Related Classifications

Cat. No.: HY-B0165A