Pravastatin (Synonyms: CS-514)

Cat. No.: HY-B0165: Data Sheet Handling Instructions
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Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Pravastatin sodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

CAS No. : 81093-37-0

Size		Stock
5 mg		Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of Pravastatin:

Pravastatin sodium In-stock
Pravastatin-d₉ sodium Get quote

7 Publications Citing Use of MCE Pravastatin

•Research Square Preprint. 2022 Feb.

Cell Proliferation/Viability Assay

RT-PCR

Cell Imaging/Staining

: Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Growth inhibition following statin treatment of THP‐1 cells. To assess cell proliferation, 1 × 10⁴ cells were seeded in a six‐well plate and cultured with DMSO or Pravastatin (2 or 4 μM). Trypan blue dye exclusion assays were performed after 6 days of treatment (n = 4).

: Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Relative mRNA expression levels of KLF4 and DPYSL2A in THP‐1 cells treated by Pravastatin (2 or 4 μM). Total RNA was then extracted and analyzed by RT‐qPCR. Values were normalized to the GAPDH expression levels (n = 3).

: Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Cell surface expression levels of CD11b and CD14 in THP‐1 cells treated Pravastatin (2 or 4 μM) (n = 3).

: Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Morphological changes in THP‐1 cells treated with DMSO or Pravastatin (4 μM) for 6 days.

: Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Apoptosis of THP‐1 cells treated Pravastatin (2 or 4 μM). The annexin V‐positive cells were scored using flow cytometric analysis (n = 3).

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Biological Activity
Purity & Documentation
References
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Description

Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM^[1].

IC₅₀ & Target

HMG-CoA reductase^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	190 μM Compound: Pravastatin	Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting	[PMID: 22541068]
HEK293	IC₅₀	3.6 μM Compound: Pravastatin	Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting	[PMID: 22541068]
HEK293	IC₅₀	62 μM Compound: Pravastatin	Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting	[PMID: 22541068]
HepG2	IC₅₀	0.43 μM Compound: Pravastatin	In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]acetate In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]acetate	[PMID: 7650673]
HepG2	IC₅₀	5100 nM Compound: Pravastatin	In vitro inhibitory activity was evaluated on cholesterol biosynthesis in HepG2 cells In vitro inhibitory activity was evaluated on cholesterol biosynthesis in HepG2 cells	[PMID: 14741258]
HepG2	IC₅₀	> 10 μM Compound: Pravastatin	In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]mevalonate In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]mevalonate	[PMID: 7650673]
Hepatocyte	IC₅₀	17 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat hepatocytes Inhibition of cholesterol synthesis in rat hepatocytes	[PMID: 18072721]
Hepatocyte	IC₅₀	17 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat hepatocyte Inhibition of cholesterol synthesis in rat hepatocyte	[PMID: 18155906]
Hepatocyte	IC₅₀	29 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat hepatocytes assessed as incorporation of [14C]acetate into cholesterol Inhibition of cholesterol synthesis in rat hepatocytes assessed as incorporation of [14C]acetate into cholesterol	[PMID: 18412317]
L6	IC₅₀	1519 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol	[PMID: 18412317]
L6	IC₅₀	7550 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat L6 myocyte Inhibition of cholesterol synthesis in rat L6 myocyte	[PMID: 18155906]
L6	IC₅₀	7600 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat L6 cells Inhibition of cholesterol synthesis in rat L6 cells	[PMID: 18072721]
S2	IC₅₀	13.7 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	15.6 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	352 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in hOAT2-expressing S2 cells TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in hOAT2-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	408 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in hOAT1-expressing S2 cells TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in hOAT1-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	449 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in rOAT2-expressing S2 cells TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in rOAT2-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	591 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT4-expressing S2 cells TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT4-expressing S2 cells	[PMID: 14978359]

In Vitro

Pravastatin (CS-514) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

424.53

Formula

C₂₃H₃₆O₇

CAS No.

81093-37-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@@H](C[C@@H](O)CC(O)=O)CC[C@@H]([C@H](C=C1)C)[C@@](C1=C[C@@H](O)C2)([H])[C@H]2OC([C@@H](C)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. [Content Brief]

Pravastatin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pravastatin81093-37-0CS-514CS514CS 514AutophagyHMG-CoA Reductase (HMGCR)Inhibitorinhibitorinhibit

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