Cat. No.: HY-B0165

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Pravastatin

(Synonyms: CS-514)

8 Cited Publications

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Based on 8 publication(s) in Google Scholar

Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

For research use only. We do not sell to patients.

CAS No.: 81093-37-0
Formula: C₂₃H₃₆O₇
Molecular Weight:424.53

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Data Sheet (269 KB)

Pravastatin Chemical Structure

CAS No.: 81093-37-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (8)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM^[1].

IC₅₀ & Target

HMG-CoA reductase^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	190 μM Compound: Pravastatin	Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting	[PMID: 22541068]
HEK293	IC₅₀	3.6 μM Compound: Pravastatin	Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting	[PMID: 22541068]
HEK293	IC₅₀	62 μM Compound: Pravastatin	Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting	[PMID: 22541068]
Hepatocyte	IC₅₀	17 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat hepatocytes Inhibition of cholesterol synthesis in rat hepatocytes	[PMID: 18072721]
Hepatocyte	IC₅₀	17 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat hepatocyte Inhibition of cholesterol synthesis in rat hepatocyte	[PMID: 18155906]
Hepatocyte	IC₅₀	29 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat hepatocytes assessed as incorporation of [14C]acetate into cholesterol Inhibition of cholesterol synthesis in rat hepatocytes assessed as incorporation of [14C]acetate into cholesterol	[PMID: 18412317]
HepG2	IC₅₀	>10 μM Compound: Pravastatin	In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]mevalonate In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]mevalonate	[PMID: 7650673]
HepG2	IC₅₀	0.43 μM Compound: Pravastatin	In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]acetate In vitro ability to inhibit cholesterol biosynthesis in HepG2 cells in culture from [14C]acetate	[PMID: 7650673]
HepG2	IC₅₀	5100 nM Compound: Pravastatin	In vitro inhibitory activity was evaluated on cholesterol biosynthesis in HepG2 cells In vitro inhibitory activity was evaluated on cholesterol biosynthesis in HepG2 cells	[PMID: 14741258]
L6	IC₅₀	1519 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol	[PMID: 18412317]
L6	IC₅₀	7550 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat L6 myocyte Inhibition of cholesterol synthesis in rat L6 myocyte	[PMID: 18155906]
L6	IC₅₀	7600 nM Compound: pravastatin	Inhibition of cholesterol synthesis in rat L6 cells Inhibition of cholesterol synthesis in rat L6 cells	[PMID: 18072721]
S2	IC₅₀	13.7 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	15.6 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	352 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in hOAT2-expressing S2 cells TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in hOAT2-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	408 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in hOAT1-expressing S2 cells TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in hOAT1-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	449 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in rOAT2-expressing S2 cells TP_TRANSPORTER: inhibition of PGF2alpha uptake (PGF2: 50nM) in rOAT2-expressing S2 cells	[PMID: 14978359]
S2	IC₅₀	591 μM Compound: Pravastatin	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT4-expressing S2 cells TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT4-expressing S2 cells	[PMID: 14978359]

In Vitro

Pravastatin (CS-514) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 81093-37-0
Appearance Solid
Molecular Weight 424.53
Formula C₂₃H₃₆O₇
Color Off-white to light yellow
SMILES

O[C@@H](C[C@@H](O)CC(O)=O)CC[C@@H]([C@H](C=C1)C)[C@@](C1=C[C@@H](O)C2)([H])[C@H]2OC([C@@H](C)CC)=O
Synonyms

CS-514
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (8)

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Cell Syst

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]

2018 Apr 25;6(4):424-443.e7. PMID: 29655704
Phytother Res

Syringin Protects Against Doxorubicin-Induced Cardiotoxicity via Apelinr-Dependent Activation of the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Antioxidant Pathway. [Abstract]

2026 Mar 26. PMID: 41883153
Front Cell Dev Biol

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis. [Abstract]

2022 Mar 3;10:806081. PMID: 35309902
Front Cell Dev Biol

Construction of Escherichia coli Whole-Cell Biosensors for Statin Efficacy and Production Test. [Abstract]

2020 May 28;8:404. PMID: 32671060
Chin J Integr Med

Treg Immunomodulation Contributes to the Anti-atherosclerotic Effects of Huxin Formula in ApoE-/- Mice. [Abstract]

2024 May 16. PMID: 38753277
FEBS Open Bio

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis. [Abstract]

2025 Aug 8. PMID: 40781787

Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Growth inhibition following statin treatment of THP‐1 cells. To assess cell proliferation, 1 × 10⁴ cells were seeded in a six‐well plate and cultured with DMSO or Pravastatin (2 or 4 μM). Trypan blue dye exclusion assays were performed after 6 days of treatment (n = 4).

Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Relative mRNA expression levels of KLF4 and DPYSL2A in THP‐1 cells treated by Pravastatin (2 or 4 μM). Total RNA was then extracted and analyzed by RT‐qPCR. Values were normalized to the GAPDH expression levels (n = 3).

Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Cell surface expression levels of CD11b and CD14 in THP‐1 cells treated Pravastatin (2 or 4 μM) (n = 3).

Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Morphological changes in THP‐1 cells treated with DMSO or Pravastatin (4 μM) for 6 days.

Pravastatin purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]

Apoptosis of THP‐1 cells treated Pravastatin (2 or 4 μM). The annexin V‐positive cells were scored using flow cytometric analysis (n = 3).
bioRxiv

2026 May 22.
Research Square Preprint

2022 Feb.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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