Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738

  • Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7. doi: 10.1016/j.bmcl.2003.11.072.
Masae Sawada  1 ,  Ken ichi Washizuka ,  Hiroyuki Okumura
Affiliations
  • 1. Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co Ltd, 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan. [email protected]
PMID: 14741258 DOI: 10.1016/j.bmcl.2003.11.072
Abstract

The synthesis and biological properties of a novel squalene epoxidase inhibitor, FR194738, are described. This compound displayed potent in vitro inhibitory activities against squalene epoxidase and Cholesterol synthesis, and lowered plasma Cholesterol and triglyceride levels in dogs.

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