1. Metabolic Enzyme/Protease
    Autophagy
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
  3. Fluvastatin

Fluvastatin (Synonyms: XU 62-320 free acid)

Cat. No.: HY-14664
Handling Instructions

Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

For research use only. We do not sell to patients.

Fluvastatin Chemical Structure

Fluvastatin Chemical Structure

CAS No. : 93957-54-1

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Description

Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].

IC50 & Target

IC50: 8 nM (HMG-CoA reductase)[1].

In Vitro

Fluvastatin (XU 62-320 free acid) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin (XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

411.47

Formula

C₂₄H₂₆FNO₄

CAS No.
SMILES

O=C(O)C[[email protected]](O)C[[email protected]](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3.[Relative sereochemsitry]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FluvastatinXU 62-320HMG-CoA Reductase (HMGCR)AutophagyHMG-CoAreductasevascularsmoothmuscleoxidativestressNrf2-dependentantioxidantpathwayInhibitorinhibitorinhibit

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Fluvastatin
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HY-14664
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