1. Metabolic Enzyme/Protease
    Autophagy
    Apoptosis
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Ferroptosis
  3. Fluvastatin sodium

Fluvastatin sodium (Synonyms: XU 62-320)

Cat. No.: HY-14664A Purity: 99.48%
Handling Instructions

Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

For research use only. We do not sell to patients.

Fluvastatin sodium Chemical Structure

Fluvastatin sodium Chemical Structure

CAS No. : 93957-55-2

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Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Fluvastatin sodium:

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Description

Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].

IC50 & Target

IC50: 8 nM (HMG-CoA reductase)[1]

In Vitro

Fluvastatin sodium (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin (XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

433.45

Formula

C₂₄H₂₅FNNaO₄

CAS No.
SMILES

O=C(O[Na])C[[email protected]](O)C[[email protected]](O)/C=C/C(N1C(C)C)=C(C2=CC=C(F)C=C2)C3=C1C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (115.35 mM; Need ultrasonic)

DMSO : 50 mg/mL (115.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3071 mL 11.5354 mL 23.0707 mL
5 mM 0.4614 mL 2.3071 mL 4.6141 mL
10 mM 0.2307 mL 1.1535 mL 2.3071 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.48%

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Keywords:

FluvastatinXU 62-320HMG-CoA Reductase (HMGCR)AutophagyFerroptosisHMG-CoAreductasevascularsmoothmuscleoxidativestressNrf2-dependentantioxidantpathwayInhibitorinhibitorinhibit

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Product Name:
Fluvastatin sodium
Cat. No.:
HY-14664A
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