1. Anti-infection
  2. Fungal
  3. Itraconazole

Itraconazole (Synonyms: R51211)

Cat. No.: HY-17514 Purity: 99.55%
Handling Instructions

Itraconazole is a triazole antifungal agent.

For research use only. We do not sell to patients.

Itraconazole Chemical Structure

Itraconazole Chemical Structure

CAS No. : 84625-61-6

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Itraconazole:

Top Publications Citing Use of Products

    Itraconazole purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2019 Sep 13;38(1):404.

    SCP2-OE GH3 cells are incubated with 10 μM itraconazole (ITR) for 48 h. The distribution of cholesterol (blue) in the different groups (Vector, SCP2-OE and SCP2-OE + ITR) are examined by filipin staining and laser confocal microscopy. Green signal, GH staining; red signal, PI nuclear staining. Scale bar, 10 μm.
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    Itraconazole is a triazole antifungal agent. IC50 Value: N/A Target: antifungal in vitro: Itraconazole is pharmacologically distinct from other azole antifungal agents in that it is the only inhibitor in this class that has been shown to inhibit both the hedgehog signaling pathway and angiogenesis[1, 2]. These distinct activities are unrelated to inhibition of the cytochrome P450 lanosterol 14 alpha-demethylase and the exact molecular targets responsible remain unidentified. Functionally, the antiangiogenic activity of itraconazole has been shown to be linked to inhibition of glycosylation, VEGFR2 phosphorylation and cholesterol biosynthesis pathways [2].Evidence suggests the structural determinants for inhibition of hedgehog signaling by itraconazole are recognizably different from those associated with antiangiogenic activity [3]. in vivo: Nine volunteers were given either 200 mg itraconazole, or matched placebo orally once daily for 4 days. On day 4, itraconazole increased the area under the midazolam concentration-time curve from 10 to 15 times (p < 0.001) and mean peak concentrations three to four times (p < 0.001) compared with the placebo phase. In psychomotor tests, the interaction was statistically significant (p < 0.05) until at least 6 hours after drug administration. Inhibition of the cytochrome P450IIIA by itraconazole may explain the observed pharmacokinetic interaction [4].

    Clinical Trial
    Molecular Weight




    CAS No.



    ClC1=C(C=CC(Cl)=C1)[[email protected]@]2(O[[email protected]@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)CC)C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7


    Room temperature in continental US; may vary elsewhere.


    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 6.25 mg/mL (8.86 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4172 mL 7.0859 mL 14.1717 mL
    5 mM 0.2834 mL 1.4172 mL 2.8343 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.62 mg/mL (0.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.62 mg/mL (0.88 mM); Clear solution

    *All of the co-solvents are provided by MCE.
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    ItraconazoleR51211R 51211R-51211FungalAutophagyInhibitorinhibitorinhibit

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