Hydroxy Itraconazole-d8
Based on 1 Customer Validation
Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 2070015-20-0
- Formula: C35H30D8Cl2N8O5
- Molecular Weight:729.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2070015-20-0
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Unlabeled Cas 112559-91-8
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Appearance Solid
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Molecular Weight 729.68
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Formula C35H30D8Cl2N8O5
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Color White to off-white
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SMILES
O=C1N(C(C([2H])([2H])[2H])([2H])C(O)([2H])C([2H])([2H])[2H])N=CN1C2=CC=C(N3CCN(C4=CC=C(OCC5OC(CN6N=CN=C6)(C7=CC=C(Cl)C=C7Cl)OC5)C=C4)CC3)C=C2
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Synonyms
R-63373-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 83.33 mg/mL (114.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (1.37 mM; ultrasonic and warming and heat to 80°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.3705 mL | 6.8523 mL | 13.7046 mL | 34.2616 mL |
| DMSO | 5 mM | 0.2741 mL | 1.3705 mL | 2.7409 mL | 6.8523 mL |
| 10 mM | 0.1370 mL | 0.6852 mL | 1.3705 mL | 3.4262 mL | |
| 15 mM | 0.0914 mL | 0.4568 mL | 0.9136 mL | 2.2841 mL | |
| 20 mM | 0.0685 mL | 0.3426 mL | 0.6852 mL | 1.7131 mL | |
| 25 mM | 0.0548 mL | 0.2741 mL | 0.5482 mL | 1.3705 mL | |
| 30 mM | 0.0457 mL | 0.2284 mL | 0.4568 mL | 1.1421 mL | |
| 40 mM | 0.0343 mL | 0.1713 mL | 0.3426 mL | 0.8565 mL | |
| 50 mM | 0.0274 mL | 0.1370 mL | 0.2741 mL | 0.6852 mL | |
| 60 mM | 0.0228 mL | 0.1142 mL | 0.2284 mL | 0.5710 mL | |
| 80 mM | 0.0171 mL | 0.0857 mL | 0.1713 mL | 0.4283 mL | |
| 100 mM | 0.0137 mL | 0.0685 mL | 0.1370 mL | 0.3426 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hydroxy Itraconazole-d8 Related Classifications
HY-12772S Related Classifications
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