1. Metabolic Enzyme/Protease
    Autophagy
    Membrane Transporter/Ion Channel
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Potassium Channel
  3. Rosuvastatin D3

Rosuvastatin D3 (Synonyms: ZD 4522 D3)

Cat. No.: HY-17504AS
Handling Instructions

Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals.

For research use only. We do not sell to patients.

Rosuvastatin D3 Chemical Structure

Rosuvastatin D3 Chemical Structure

CAS No. : 1133429-16-9

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Description

Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].

Molecular Weight

484.56

Formula

C₂₂H₂₅D₃FN₃O₆S

CAS No.

1133429-16-9

SMILES

FC(C=C1)=CC=C1C2=NC(N(C([2H])([2H])[2H])S(=O)(C)=O)=NC(C(C)C)=C2/C=C/[[email protected]@H](O)C[[email protected]@H](O)CC(O)=O

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Keywords:

Rosuvastatin D3ZD 4522 D3Rosuvastatin D 3Rosuvastatin D-3HMG-CoA Reductase (HMGCR)AutophagyPotassium ChannelKcsAether-a-go-gorelatedgenehERGcardiacrepolarizationactionpotentialdurationsAPDsQTQTcHsp70low-densitylipoproteincholesteroltriglyceridesInhibitorinhibitorinhibit

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Rosuvastatin D3
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