1. Metabolic Enzyme/Protease
    Apoptosis
  2. Endogenous Metabolite
    Apoptosis
  3. Ecdysone

Ecdysone (Synonyms: α-Ecdysone)

Cat. No.: HY-N0179
Handling Instructions

Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979).

For research use only. We do not sell to patients.

Ecdysone Chemical Structure

Ecdysone Chemical Structure

CAS No. : 3604-87-3

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Description

Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979)[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Ecdysone (α-Ecdysone; 100 nM; for 48 hours) causes renal tubular inner medullary collecting duct cells (IMCD) apoptosis[1].
Ecdysone (10, 100 nM; for 48 hours) induces the expression of a-smooth muscle actin (SMA), a standard mesenchymal marker in a dose dependent fashion in inner medullary collecting duct cells (IMCD). Ecdysone elevates the expression of cleaved caspase 3 in a dose dependent fashion[1].
Ecdysone (10, 100 nM; for 12, 24 hours) suppresses cell motility and scratch wound closure to a comparable extent[1].
Ecdysone treatments (100 nM; for 24, 48 hours) induces a branched spindle mesenchymal-like cell shape[1].

Apoptosis Analysis[1]

Cell Line: Inner medullary collecting duct cells (IMCD)
Concentration: 100 nM
Incubation Time: For 48 hours
Result: Caused renal tubular cell apoptosis.

Western Blot Analysis[1]

Cell Line: IMCD cells
Concentration: 10, 100 nM
Incubation Time: For 48 hours
Result: Induced the expression of a-smooth muscle actin (SMA), a standard mesenchymal marker in a dose dependent fashion.
In Vivo

Ecdysone (α-Ecdysone; 6 µg/g/day; SC; for 14 days) evidently impaires kidney function marked by a statistically significant increase in BUN levels and amplifies renal expression of α-SMA in male C57BL/6 mice aged 10 weeks. Ecdysone confers an MR dependent nephropathic effect[1].

Molecular Weight

464.63

Formula

C₂₇H₄₄O₆

CAS No.

3604-87-3

SMILES
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Keywords:

Ecdysoneα-EcdysoneEndogenous MetaboliteApoptosissteroidhormonemineralocorticoidreceptorMRcoordinatingdevelopmentaltransitionshomeostaticsleepregulationmetabolite20-hydroxyecdysoneCrustecdysone20EInhibitorinhibitorinhibit

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