3604-87-3
3604-87-3
Chemical Structure
Ecdysone
Synonym(s): α-Ecdysone
- CAS 番号: 3604-87-3
- Formula:C27H44O6
- Molecular Weight:464.63
IUPAC Name: (2S,3R,5R,9R,10R,13R,14S,17R)-17-((2S,3R)-3,6-dihydroxy-6-methylheptan-2-yl)-2,3,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one
InChIKey: UPEZCKBFRMILAV-JMZLNJERSA-N
SMILES: O[C@]([C@@]12C)(CC[C@]1([H])[C@H](C)[C@H](O)CCC(C)(O)C)C([C@@](CC2)([H])[C@]([C@@]3([H])C[C@H]4O)(C[C@@H]4O)C)=CC3=O
Biological Activity: Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979)[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Ecdysone | 96.10% | Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979). | ||||||||||||||||||||
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Inokosterone | 99.39% | Inokosterone is a potential agent target of estrogen receptor 1 in rheumatoid arthritis patients. | ||||||||||||||||||||
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Makisterone A | 96.64% | Makisterone A, a 28-carbon moulting hormone, has been identified as the major free pupal ecdysteroid in the honey bee, Apis mellifera. | ||||||||||||||||||||
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Ponasterone A | 99.45% | Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly. | ||||||||||||||||||||
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2-Deoxyecdysone | 2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects. | |||||||||||||||||||||
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25,26-Didehydroponasterone | 25,26-Didehydroponasterone (Compound 1) is a phytoecdysteroid found in the roots of Klaseopsis chinensis (Compositae). | |||||||||||||||||||||
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25S-Inokosterone | 99.47% | 25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research. | ||||||||||||||||||||
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25R-Inokosterone | 98.76% | 25R-Inokosterone is a phytoecdysone isolated from Achyranthis Radix. | ||||||||||||||||||||
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Crustecdysone (Standard) | 98.82% | Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179). | ||||||||||||||||||||
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Polyporusterone A | 99.98% | Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis). | ||||||||||||||||||||
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Rhapontisterone B | Rhapontisterone B is a Steroids product that can be isolated from the herbs of Rhaponticum uniflorum (L.) DC.. | |||||||||||||||||||||
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References
- [1]. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645. [Content Brief]
- [2]. Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3β Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225. [Content Brief]
