3604-87-3
Chemical Structure
Ecdysone
Synonym(s): α-Ecdysone
- CAS 番号: 3604-87-3
- Formula:C27H44O6
- Molecular Weight:464.63
IUPAC Name: (2S,3R,5R,9R,10R,13R,14S,17R)-17-((2S,3R)-3,6-dihydroxy-6-methylheptan-2-yl)-2,3,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one
InChIKey: UPEZCKBFRMILAV-JMZLNJERSA-N
SMILES: O[C@]([C@@]12C)(CC[C@]1([H])[C@H](C)[C@H](O)CCC(C)(O)C)C([C@@](CC2)([H])[C@]([C@@]3([H])C[C@H]4O)(C[C@@H]4O)C)=CC3=O
Biological Activity: Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979)[1][2].
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Ecdysone | 96.10% | Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979). | ||||||||||||||||||||
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Similarity Score 0.86
HY-N154912-Deoxyecdysone -
Similarity Score 0.84
HY-N6979RCrustecdysone (Standard) -
Similarity Score 0.84
HY-N8794Rhapontisterone B -
Similarity Score 0.83
HY-N1534Ponasterone A -
Similarity Score 0.81
HY-N7692Polyporusterone A -
Similarity Score 0.81
HY-121351Inokosterone -
Similarity Score 0.81
HY-N413025S-Inokosterone -
Similarity Score 0.81
HY-N413125R-Inokosterone -
Similarity Score 0.81
HY-N1966825,26-Didehydroponasterone -
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References
- [1]. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645. [Content Brief]
- [2]. Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3β Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225. [Content Brief]
