1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. COX
    Drug Metabolite
  3. 4-Methylamino antipyrine hydrochloride

4-Methylamino antipyrine hydrochloride 

Cat. No.: HY-135731A
Handling Instructions

4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.

For research use only. We do not sell to patients.

4-Methylamino antipyrine hydrochloride Chemical Structure

4-Methylamino antipyrine hydrochloride Chemical Structure

CAS No. : 856307-27-2

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Description

4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].

IC50 & Target
In Vitro

Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

253.73

Formula

C12H16ClN3O

CAS No.
SMILES

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1NC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
4-Methylamino antipyrine hydrochloride
Cat. No.:
HY-135731A
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